نوع مقاله : مقاله های پژوهشی
نویسندگان
1 دکتری تخصصی، کمیته تحقیقات دانشجویی، گروه فیزیک پزشکی، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
2 دانشیار، گروه پرتودرمانی، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
3 کارشناسی ارشد فناوری تصویربرداری پزشکی، گروه فیزیک پزشکی، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
4 کارشناسی پرتودرمانی، بیمارستان سیدالشهدا، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
5 استاد، گروه فیزیک پزشکی، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
چکیده
تازه های تحقیق
کورش صابر: Google Scholar, PubMed
احمد شانئی: Google Scholar, PubMed
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background: Radiation therapy is one of the primary treatment methods for breast cancer. Oral and pharyngeal complications are significant challenges associated with this treatment. This study aimed to compare the oral and pharyngeal complications in patients receiving radiation therapy using two techniques: conventional and hypofractionated.
Methods: In this cross-sectional analytical study, 70 breast cancer patients treated at Seyed-al-Shohada Hospital in Isfahan in 2024 were examined. The patients were divided into two groups: those receiving conventional radiation therapy (5000 cGy in 25 fractions) and those undergoing hypofractionated radiation therapy (4250 cGy in 16 fractions). Oral and pharyngeal complications were assessed and compared during treatment and up to 60 days post-treatment based on the CTCAE V5 criteria in both groups.
Findings: The findings of this study demonstrated a significantly higher incidence of acute oral and pharyngeal adverse events in the conventional radiotherapy group compared to the hypofractionated radiotherapy group
(P = 0.05). Specifically, the prevalence of moderate (grade 2) and severe (grade 3) adverse events was 17.1% and 8.5% in the conventional group, respectively, compared to 14.2% and 0% in the hypofractionated group. Data analysis indicated that the clinical variables of age, body mass index (BMI), and concurrent chemotherapy also had a significant impact on the severity of oral and pharyngeal adverse events in both treatment groups (P < 0.05).
Conclusion: This clinical study demonstrated that patients receiving hypofractionated radiation therapy experienced fewer oral and pharyngeal complications than those treated with the conventional technique.
کلیدواژهها [English]