نوع مقاله : مقاله های پژوهشی
نویسندگان
1 دانشجوی دکتری فیزیولوژی ورزشی، دانشکدهی علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران
2 استاد، گروه علوم ورزشی، دانشکدهی علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران
3 دانشیار، گروه فیزیولوژی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران
4 استادیار، گروه علوم ورزشی، دانشکدهی ادبیات و علوم انسانی، دانشگاه زابل، زابل، ایران
چکیده
تازه های تحقیق
احمد اربابی: Google Scholar ,PubMed
مهدی مقرنسی: Google Scholar ,PubMed
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Background: Gestational Diabetes Mellitus (GDM) is any degree of glucose intolerance with onset or first recognition during pregnancy. Regular exercise is important for a healthy pregnancy and can lower the risk of developing GDM. On the other hand, the crux of the matter is to find a bio predictor capable of signaling out women at risk of developing GDM as early as the very start of pregnancy. This study aimed to present the potential and significance of Spexin (SPX) in the pathogenesis of GDM.
Methods: Sixty female Wistar rats (weighting 220 ± 10g) were randomly assigned into six groups: control (Ctr) group, control+continuous aerobic training (Ctr+CON) group, control+intermittent aerobic training (Ctr+INT) group, gestational diabetes mellitus (GDM) group, GDM+continuous aerobic training (GDM+CON) group, GDM+intermittent aerobic training (GDM+INT) group. Exercise groups underwent treadmill exercise during pregnancy. Levels of insulin sensitivity and spexin were measured. A one-way ANOVA statistical test was used for statistical analysis.
Findings: Serum spexin concentration in the GDM group was significantly higher than Ctr; on the other hand, the spexin level in the GDM+CON and GDM+INT groups was considerably lower than in the GDM group. On the 20th day of gestation, the weight of the GDM group was significantly higher than that of the Ctr and training groups. The birth weight of offspring in the GDM group was significantly higher than that of the Ctr and Exc groups. Insulin sensitivity levels in the GDM+CON and GDM+INT groups were significantly lower than in the GDM group.
Conclusion: The results of this study demonstrate that both continuous and intermittent training were effective in improving GDM, but there was no statistically significant difference between the two training models. In addition, Changes in SPX levels seem to be influenced by the presence of GDM in pregnant women, with increased levels in those with GDM. It may be used as a potential factor to predict the development of GDM.
کلیدواژهها [English]