بررسی اثر مکمل کورکومین فیتوزومال بر التهاب در بیماران مولتیپل ترومای بستری در بخش مراقبت‌های ویژه

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 استاد مراقبت‌های ویژه پزشکی، گروه بیهوشی، دانشکده‌ی پزشکی، مرکز تحقیقات بیهوشی و مراقبت‌های ویژه، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 مرکز مراقبت‌های ویژه پزشکی، گروه بیهوشی، دانشکده‌ی پزشکی، مرکز تحقیقات بیهوشی و مراقبت‌های ویژه، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 دانشیار مراقبت‌های ویژه پزشکی، گروه بیهوشی، دانشکده‌ی پزشکی، مرکز تحقیقات بیهوشی و مراقبت‌های ویژه، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

4 استادیار علوم تغذیه، گروه تغذیه جامعه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

10.48305/jims.v42.i794.1086

چکیده

مقاله پژوهشی




مقدمه: ترومای متعدد، عوارض جدی دارد که خطر مرگ و میر را در بیماران افزایش می‌دهد. هدف از این مطالعه، بررسی تأثیر مکمل‌سازی با کورکومین فیتوزومال بر
(C-reactive protein) CRP در بیماران بدحال با ترومای متعدد بود.
روش‌ها: در این کارآزمایی دوسوکور، 53 بیمار با ترومای متعدد که در بخش مراقبت‌های ویژه (Intensive care units) ICU بستری شده بودند، به‌طور تصادفی دو کپسول، هر کپسول حاوی 250 میلی‌گرم فیتوزومال (مجموعاً 500 میلی‌گرم در روز) را به‌صورت تصادفی دریافت کردند. گروه مداخله یا 2 کپسول یکسان (کپسول دارونما) که هر کدام حاوی 250 میلی‌گرم مالتودکسترین به مدت 7 روز است. پارامترهای بالینی و آزمایشگاهی قبل و بعد از مداخله ارزیابی شدند.
یافته‌ها: پس از 7 روز مداخله، سطح  CRPبه‌طور معنی‌داری (0/044 = P) در کورکومین در مقایسه با گروه دارونما کاهش یافت.
نتیجه‌گیری: کورکومین فیتوزومال، تأثیر مفیدی بر فاکتور آزمایشگاهی (CRP) در بیماران بستری در بخش مراقبت‌های ویژه با ترومای متعدد داشت.

تازه های تحقیق

سعید عباسی: Google Scholar, PubMed

بابک علی کیایی: Google Scholar, PubMed

محمد باقرنیا: Google Scholar, PubMed

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effectiveness of Phytosomal Curcumin on Inflammation in Patients with Multiple Trauma Admitted to the Intensive Care Unit: A Double-Blind Randomized Placebo-Controlled Trial

نویسندگان [English]

  • Saeed Abbasi 1
  • Mahdiye Mirjalili 2
  • Babak Alikiaii 3
  • Mohammad Bagherniya 4
1 Professor, Anesthesia and Critical Care Research Center, Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
2 Anesthesia and Critical Care Research Center, Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
3 Association Professor, Anesthesia and Critical Care Research Center, Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
4 Assistant Professor, Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background:  Multiple trauma has serious complications, which increases the risk of morbidity and mortality in the patients. This study aimed to evaluate the impact of supplementation with phytosomal curcumin on CRP in critically ill patients with multiple traumas.
Methods: In this double-blind trial, 53 patients with multiple trauma who were admitted to the intensive care unit (ICU) were randomized to receive either two capsules, each capsule containing 250 mg phytosomal (a total of 500 mg daily) as an intervention group or two identical capsules (placebo capsules), each containing 250 mg maltodextrin for 7 days. Clinical and laboratory parameters were assessed before and after the intervention.
Findings: After seven days of intervention, quantitative C-reactive protein (CRP) (P = 0.044) levels significantly decreased in the curcumin compared with the placebo group.
Conclusion: Phytosomal curcumin had a beneficial effect on laboratory factor (CRP) in ICU-admitted patients with multiple trauma.

کلیدواژه‌ها [English]

  • Curcumin
  • Inflammation
  • Trauma

مراجع

  1. Scott SG, Scholten JD, Latlief GA, Humayun F, Belanger HG, Vanderploeg RD. Polytrauma Rehabilitation. In: Frontera WR, Silver JK, Rizzo TD, editors. Essentials of Physical Medicine and Rehabilitation. 2nd. ed. Philadelphia, PA: W.B. Saunders; 2008. p. 787-91.
  2. Soucacos PN, Johnson EO: Multiple Trauma. In: Fink G, editor. Encyclopedia of Stress. 2nd. edn. . New York, NY: Academic Press; 2007. p. 795-800.
  3. Lord JM, Midwinter MJ, Chen Y-F, Belli A, Brohi K, Kovacs EJ, et al. The systemic immune response to trauma: an overview of pathophysiology and treatment. Lancet 2014; 384(9952): 1455-65.
  4. Pape HC, Moore EE, McKinley T, Sauaia A. Pathophysiology in patients with polytrauma. Injury 2022; 53(7): 2400-12.
  5. Kotha RR, Luthria DL. Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects. Molecules 2019; 24(16):
  6. El-Saadony MT, Yang T, Korma SA, Sitohy M, Abd El-Mageed TA, Selim S, et al. Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review. Front Nutr 2022; 9: 1040259.
  7. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J 2013; 15(1): 195-218.
  8. Mohseni M, Sahebkar A, Askari G, Johnston TP, Alikiaii B, Bagherniya M. The clinical use of curcumin on neurological disorders: An updated systematic review of clinical trials. Phytother Res 2021; 35(12): 6862-82.
  9. Mahdavi A, Moradi S, Askari G, Iraj B, Sathyapalan T, Guest PC, Bagherniya M, Sahebkar A. Effect of curcumin on glycemic control in patients with type 2 diabetes: a systematic review of randomized clinical trials. Adv Exp Med Biol 2021; 1291: 139-49.
  10. Alikiaii B, Bagherniya M, Askari G, Sathyapalan T, Sahebkar A. Evaluation of the effect of curcumin on pneumonia: A systematic review of preclinical studies. Phytother Res 2021; 35(4): 1939-52.
  11. Alikiaii B, Bagherniya M, Askari G, Johnston TP, Sahebkar A. The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective. Biofactors 2021; 47(1): 19-40.
  12. Momtazi-Borojeni AA, Haftcheshmeh SM, Esmaeili SA, Johnston TP, Abdollahi E, Sahebkar A. Curcumin: A natural modulator of immune cells in systemic lupus erythematosus. Autoimmun Rev 2018; 17(2): 125-35.
  13. Parsamanesh N, Moossavi M, Bahrami A, Butler AE, Sahebkar A.Therapeutic potential of curcumin in diabetic complications. Pharmacol Res 2018; 136: 181-93.
  14. Heidari H, Bagherniya M, Majeed M, Sathyapalan T, Jamialahmadi T, Sahebkar A. Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies. Phytother Res 2023; 37(4): 1462-87.
  15. Ghasemi F, Bagheri H, Barreto GE, Read MI, Sahebkar A. Effects of Curcumin on Microglial Cells. Neurotox Res 2019; 36(1): 12-26.
  16. Heidari H, Bagherniya M, Majeed M, Sathyapalan T, Jamialahmadi T, Sahebkar A. Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies. Phytother Res 2023; 37(4): 1462-87.
  17. Hassanizadeh S, Shojaei M, Bagherniya M, Orekhov AN, Sahebkar A. Effect of nano-curcumin on various diseases: A comprehensive review of clinical trials. Biofactors 2023; 49(3): 512-33.
  18. Heidari Z, Daei M, Boozari M, Jamialahmadi T, Sahebkar A. Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence. Phytother Res 2022; 36(4): 1442-58.
  19. Karimi A, Naeini F, Niazkar HR, Tutunchi H, Musazadeh V, Mahmoodpoor A, et al. Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices, endothelial function, clinical outcomes and nutritional status. Food Funct 2022; 13(12): 6596-612.
  20. Karimi A, Pourreza S, Vajdi M, Mahmoodpoor A, Sanaie S, Karimi M, et al. Evaluating the effects of curcumin nanomicelles on clinical outcome and cellular immune responses in critically ill sepsis patients: A randomized, double-blind, and placebo-controlled trial. Front Nutr 2022; 9: 1037861.
  21. Zahedi H, Hosseinzadeh-Attar MJ, Shadnoush M, Sahebkar A, Barkhidarian B, Sadeghi O, et al. Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: A randomized double-blind placebo-controlled trial. Phytother Res 2021; 35(8): 4605-15.
  22. Khayatan D, Razavi SM, Arab ZN, Niknejad AH, Nouri K, Momtaz S, et al. Protective effects of curcumin against traumatic brain injury. Biomed Pharmacother 2022; 154: 113621.
  23. Allam AN, Komeil IA, Abdallah OY. Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization. Acta Pharm 2015; 65(3): 285-97.
  24. Lopresti AL. The problem of curcumin and its bioavailability: could its gastrointestinal influence contribute to its overall health-enhancing effects? Adv Nutr 2018; 9(1):41-50.
  25. Ma Z, Wang N, He H, Tang X. Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application. J Control Release 2019; 316: 359-80.
  26. Mirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z, Sahebkar A. Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother 2017; 85: 102-12.
  27. Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition 2015; 31(6): 781-6.
  28. Marczylo TH, Steward WP, Gescher AJ. Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method. J Agric Food Chem 2009; 57(3): 797-803.
  29. Marczylo TH, Verschoyle RD, Cooke DN, Morazzoni P, Steward WP, Gescher AJ. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol 2007; 60(2): 171-7.
  30. Shojaei M, Sahebkar A, Khorvash F, Fallahpour S, Askari G, Bagherniya M. The effects of phytosomal curcumin supplementation on clinical symptoms, and inflammatory and oxidative stress biomarkers in patients with migraine: A protocol for a randomized double-blind placebo-controlled trial. Avicenna J Phytomed 2023; 13(1): 45-57.
  31. Wu A, Ying Z, Schubert D, Gomez-Pinilla F. Brain and spinal cord interaction: a dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma. Neurorehabil Neural Repair 2011; 25(4): 332-42.
  32. Vahdat M, Hosseini SA, Soltani F, Cheraghian B, Namjoonia M. The effects of Taurine supplementation on inflammatory markers and clinical outcomes in patients with traumatic brain injury: a double-blind randomized controlled trial. Nutr J 2021; 20(1): 53.
  33. Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol 2006; 197(2): 309-17.
  34. Sabir S, Umer N, Shoaib M, Zulfiqar S. Correlation of interleukin-10 with Glasgow coma scale in patients of stroke. Pakistan Journal of Medical and Health Sciences 2016, 10(1):63-65.
  35. Ali Hosseinian S, Mehrzad J, Reza Mirhafez S, Saeidi J, Zhiani R, Sahebkar A. Evaluation of the effect of phytosomal curcuminoids on oxidative stress and inflammatory markers in NAFLD: A randomized double-blind placebo-controlled trial. Journal of Functional Foods 2022; 96: 105202.
  36. Wongcharoen W, Phrommintikul A. The protective

    role of curcumin in cardiovascular diseases. Int J Cardiol 2009; 133(2): 145-151.
  37. Panahi Y, Ghanei M, Bashiri S, Hajihashemi A, Sahebkar A. Short-term curcuminoid supplementation for chronic pulmonary complications due to sulfur mustard intoxication: positive results of a randomized double-blind placebo-controlled trial. Drug Res (Stuttg) 2015; 65(11): 567-73.
  38. Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. Eur J Nutr 2020; 59(2): 477-83.
  39. Zhang D-w, Fu M, Gao S-H, Liu J-L. Curcumin and diabetes: a systematic review. Evid Based Complement Alternat Med 2013; 2013: 636053.
  40. Gorabi AM, Abbasifard M, Imani D, Aslani S, Razi B, Alizadeh S, et al. Effect of curcumin on C-reactive protein as a biomarker of systemic inflammation: An updated meta-analysis of randomized controlled trials. Phytother Res 2022; 36(1): 85-97.

Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin Nutr 2015; 34(6): 1101-8.

مجله دانشکده پزشکی اصفهان
دوره 42، شماره 794
هفته 2، بهمن
بهمن و اسفند 1403
صفحه 1086-1094

فایل ها

سابقه مقاله

  • تاریخ دریافت: 03 تیر 1403
  • تاریخ پذیرش: 15 مهر 1403

هم رسانی

ارجاع به این مقاله

آمار