مجله دانشکده پزشکی اصفهان

مجله دانشکده پزشکی اصفهان

بررسی اثر مکمل کورکومین فیتوزومال بر التهاب در بیماران مولتیپل ترومای بستری در بخش مراقبت‌های ویژه

نوع مقاله : مقاله های پژوهشی

نویسندگان
سعید عباسی 1
مهدیه میرجلیلی 2
بابک علی کیایی 3
محمد باقرنیا 4
1 استاد مراقبت‌های ویژه پزشکی، گروه بیهوشی، دانشکده‌ی پزشکی، مرکز تحقیقات بیهوشی و مراقبت‌های ویژه، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
2 مرکز مراقبت‌های ویژه پزشکی، گروه بیهوشی، دانشکده‌ی پزشکی، مرکز تحقیقات بیهوشی و مراقبت‌های ویژه، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
3 دانشیار مراقبت‌های ویژه پزشکی، گروه بیهوشی، دانشکده‌ی پزشکی، مرکز تحقیقات بیهوشی و مراقبت‌های ویژه، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
4 استادیار علوم تغذیه، گروه تغذیه جامعه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
10.48305/jims.v42.i794.1086
چکیده
مقاله پژوهشی




مقدمه: ترومای متعدد، عوارض جدی دارد که خطر مرگ و میر را در بیماران افزایش می‌دهد. هدف از این مطالعه، بررسی تأثیر مکمل‌سازی با کورکومین فیتوزومال بر
(C-reactive protein) CRP در بیماران بدحال با ترومای متعدد بود.
روش‌ها: در این کارآزمایی دوسوکور، 53 بیمار با ترومای متعدد که در بخش مراقبت‌های ویژه (Intensive care units) ICU بستری شده بودند، به‌طور تصادفی دو کپسول، هر کپسول حاوی 250 میلی‌گرم فیتوزومال (مجموعاً 500 میلی‌گرم در روز) را به‌صورت تصادفی دریافت کردند. گروه مداخله یا 2 کپسول یکسان (کپسول دارونما) که هر کدام حاوی 250 میلی‌گرم مالتودکسترین به مدت 7 روز است. پارامترهای بالینی و آزمایشگاهی قبل و بعد از مداخله ارزیابی شدند.
یافته‌ها: پس از 7 روز مداخله، سطح  CRPبه‌طور معنی‌داری (0/044 = P) در کورکومین در مقایسه با گروه دارونما کاهش یافت.
نتیجه‌گیری: کورکومین فیتوزومال، تأثیر مفیدی بر فاکتور آزمایشگاهی (CRP) در بیماران بستری در بخش مراقبت‌های ویژه با ترومای متعدد داشت.

تازه های تحقیق

سعید عباسی: Google Scholar, PubMed

بابک علی کیایی: Google Scholar, PubMed

محمد باقرنیا: Google Scholar, PubMed

کلیدواژه‌ها
کورکومین
التهاب
تروما
موضوعات

عنوان مقاله English

The Effectiveness of Phytosomal Curcumin on Inflammation in Patients with Multiple Trauma Admitted to the Intensive Care Unit: A Double-Blind Randomized Placebo-Controlled Trial

نویسندگان English

Saeed Abbasi 1
Mahdiye Mirjalili 2
Babak Alikiaii 3
Mohammad Bagherniya 4
1 Professor, Anesthesia and Critical Care Research Center, Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
2 Anesthesia and Critical Care Research Center, Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
3 Association Professor, Anesthesia and Critical Care Research Center, Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
4 Assistant Professor, Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده English

Background:  Multiple trauma has serious complications, which increases the risk of morbidity and mortality in the patients. This study aimed to evaluate the impact of supplementation with phytosomal curcumin on CRP in critically ill patients with multiple traumas.
Methods: In this double-blind trial, 53 patients with multiple trauma who were admitted to the intensive care unit (ICU) were randomized to receive either two capsules, each capsule containing 250 mg phytosomal (a total of 500 mg daily) as an intervention group or two identical capsules (placebo capsules), each containing 250 mg maltodextrin for 7 days. Clinical and laboratory parameters were assessed before and after the intervention.
Findings: After seven days of intervention, quantitative C-reactive protein (CRP) (P = 0.044) levels significantly decreased in the curcumin compared with the placebo group.
Conclusion: Phytosomal curcumin had a beneficial effect on laboratory factor (CRP) in ICU-admitted patients with multiple trauma.

کلیدواژه‌ها English

Curcumin
Inflammation
Trauma
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مجله دانشکده پزشکی اصفهان
دوره 42، شماره 794
هفته 2، بهمن
بهمن و اسفند 1403
صفحه 1086-1094

  • تاریخ دریافت 03 تیر 1403
  • تاریخ پذیرش 15 مهر 1403