مجله دانشکده پزشکی اصفهان

مجله دانشکده پزشکی اصفهان

بررسی ارتباط میان آلودگی آب (آرسنیک) و ایجاد زایمان زودرس

نوع مقاله : Original Article(s)

نویسندگان
مینو موحدی 1
مریم دهقان 2
مینا گلواری نژاد 3
1 دانشیار، گروه زنان و زایمان، دانشکده‌ی پزشکی، مرکز آموزشی درمانی الزهرا (س)، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
2 استادیار، گروه زنان و زایمان، دانشکده‌ی پزشکی، مرکز آموزشی درمانی شهید بهشتی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
3 گروه زنان و زایمان، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
10.48305/jims.v42.i796.1137
چکیده
مقاله پژوهشی




مقدمه: اعتقاد بر این است که علت بسیاری از پیامدهای نامطلوب بارداری مانند زایمان زودرس، آلودگی محیطی است. یکی از مهم‌ترین آلاینده‌ها، آرسنیک موجود در آب است. هدف از این مطالعه، بررسی رابطه بین مسمومیت با آرسنیک و ایجاد زایمان زودرس بوده است.
روش‌ها: این مطالعه مقطعی بر روی بیماران مبتلا به زایمان زودرس در مقایسه با گروه شاهد با زایمان ترم انجام شد. از همه‌ی بیماران برای ارزیابی سطح آرسنیک نمونه‌ی ادرار گرفته شد.
یافته‌ها: میانگین سنی در گروه مادران بدون زایمان زودرس 4/63 ± 24/45 سال و در گروه مادران زایمان زودرس 18/94 ± 25/3 سال بوده است (0/231 = P). میانگین سطح آرسنیک در گروه مادران بدون زایمان زودرس 20/44 ± 8/24 و در گروه مادران با زایمان زودرس 7/05 ± 22/75 بود (0/368 = P). در گروه مادران با زایمان زودرس late، سطح آرسنیک با میانگین 24/15 ± 4/63 به طور معنی‌داری بالاتر بوده است (0/045 = P) در حالی که این نتیجه در موارد مادران با زایمان زودرس early با میانگین سطح آرسنیک 6/12 ± 21/05 وجود نداشت (0/78 = P).
نتیجه‌گیری: بین میزان آرسنیک ادرار و وقوع زایمان زودرس رابطه‌ی معنی‌داری یافت نشد. اگرچه داده‌های ما رابطه‌ای را با زایمان زودرس late و سطح آرسنیک نشان داد. آزمایشات جامع‌تری برای بررسی داده‌های مطالعاتی ما توصیه می‌شود.

تازه های تحقیق

مینو موحدی: Google Scholar 

 

کلیدواژه‌ها
آلاینده‌های شیمیایی آب
زایمان زودرس
آرسنیک

موضوعات

عنوان مقاله English

Investigating the Relationship between Water Pollution (Arsenic) and Preterm Birth

نویسندگان English

Minoo Mohvahedi 1
Maryam Dehghan 2
Mina Golvarinejad 3
1 Associate Professor, Department of Obstetrics & Gynecology, School of Medicine, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Department of Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده English

 
Background: Many adverse pregnancy outcomes, such as preterm birth, are believed to be caused by environmental pollution. One of the most significant polluters is arsenic in the water. In this study, we aimed to evaluate the relationship between arsenic and the development of preterm birth.
Methods: This cross-sectional study was conducted on patients with preterm birth compared with a normal control group. All patients underwent urine samples to assess arsenic levels.
Findings: The mean age in the group of mothers without preterm birth was 24.45 ± 4.63, and the mean age in the group of mothers with preterm birth was 25.18 ± 3.94 (P = 0.231). The mean arsenic level in mothers without preterm birth was 20.44 ± 8.24, and the mean arsenic level in the group of mothers with preterm birth was 22.75 ± 7.05 (P = 0.368). In late preterm birth, the mean Arsenic level was higher with slight significance, with a mean of 24.15 ± 4.63 (P = 0.045). This observation didn’t exist in early preterm birth with the mean Arsenic level of 21.05 ± 6.12 (P = 0.78).
Conclusion: We couldn’t find any significant relationship between urine arsenic levels and the occurrence of preterm birth. However, our data showed a relationship between late preterm birth and Arsenic levels. More comprehensive trials are recommended.

کلیدواژه‌ها English

Chemical water pollutants
Arsenic
Preterm birth
  1. Zakariaee SS, Salawati Ghasemi S, Sheikh Zakaryaee N. The relationship between maternal body mass index and the incidence of preterm delivery in iranian pregnant women: a systematic review [in Persian]. Nursing and Midwifery Journal. 2023; 20(11): 908-21.
  2. Giouleka S, Tsakiridis I, Kostakis N, Koutsouki G, Kalogiannidis I, Mamopoulos A, et al. Preterm labor: a comprehensive review of guidelines on diagnosis, management, prediction and prevention. Obstet Gynecol Surv 2022; 77(5): 302-17.
  3. Naser AY, Al-Shehri H, Altamimi N, Alrasheed A, Albalawi L, editors. Profile of hospital admissions due to preterm labor and delivery in England. Healthcare (Basel) 2023; 11(2): 163.
  4. Koteswari P, Lakshmi PA, Yaseen M, Sultana S, Tabassum A, Soumya P, et al. Preterm birth: causes and complications observed in tertiary care hospitals. Cell Mol Biomed Rep 2022; 2(4): 202-12.
  5. Huang W, Ural S, Zhu Y. Preterm labor tests: current status and future directions. Crit Rev Clin Lab Sci 2022; 59(4): 278-96.
  6. Liu Y, Gao L. Preterm labor, a syndrome attributed to the combination of external and internal factors. Maternal-Fetal Medicine 2022; 4(1): 61-71.
  7. Lin L, Yang H, Xu X. Effects of water pollution on human health and disease heterogeneity: a review. Front Environ Sci 2022; 10: 880246.
  8. Xu H, Jia Y, Sun Z, Su J, Liu QS, Zhou Q, et al. Environmental pollution, a hidden culprit for health issues. Eco Environ Health 2022; 1(1): 31-45.
  9. Chen J, Fang J, Zhang Y, Xu Z, Byun H-M, Li P-h, et al. Associations of adverse pregnancy outcomes with high ambient air pollution exposure: Results from the Project ELEFANT. S Sci Total Environ 2021; 761: 143218.
  10. Jacobs M, Zhang G, Chen S, Mullins B, Bell M, Jin L, et al. The association between ambient air pollution and selected adverse pregnancy outcomes in China: a systematic review. Sci Total Environ 2017; 579: 1179-92.
  11. Johnson NM, Hoffmann AR, Behlen JC, Lau C, Pendleton D, Harvey N, et al. Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter. Environ Health Prev Med 2021; 26(1): 72.
  12. Al‐Gubory KH. Multiple exposures to environmental pollutants and oxidative stress: Is there a sex specific risk of developmental complications for fetuses? Birth Defects Res C Embryo Today 2016; 108(4): 351-64.
  13. Bai W, Li Y, Niu Y, Ding Y, Yu X, Zhu B, et al. Association between ambient air pollution and pregnancy complications: a systematic review and meta-analysis of cohort studies. Environ Res 2020; 185: 109471.
  14. Al-Gubory KH. Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development. Reprod Biomed Online 2014; 29(1): 17-31.
  15. Boyles AL, Beverly BE, Fenton SE, Jackson CL, Jukic AMZ, Sutherland VL, et al. Environmental factors involved in maternal morbidity and mortality. J Womens Health (Larchmt) 2021; 30(2): 245-52.
  16. Shih Y-H, Bryan MS, Argos M. Association between prenatal arsenic exposure, birth outcomes, and pregnancy complications: An observational study within the National Children's Study cohort. Environ Res 2020; 183: 109182.
  17. Bundschuh J, Schneider J, Alam MA, Niazi NK, Herath I, Parvez F, et al. Seven potential sources of arsenic pollution in Latin America and their environmental and health impacts. Sci Total Environ 2021; 780: 146274.
  18. Weerasundara L, Ok Y-S, Bundschuh J. Selective removal of arsenic in water: A critical review. Environ Pollut 2021; 268(Pt B): 115668.
  19. Rahaman MS, Rahman MM, Mise N, Sikder MT, Ichihara G, Uddin MK, et al. Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management. Environ Pollut 2021; 289: 117940.
  20. Chen QY, Costa M. Arsenic: a global environmental challenge. Annu Rev Pharmacol Toxicol 2021; 61: 47-63.
  21. Palma-Lara I, Martínez-Castillo M, Quintana-Pérez J, Arellano-Mendoza M, Tamay-Cach F, Valenzuela-Limón O, et al. Arsenic exposure: A public health problem leading to several cancers. Regul Toxicol Pharmacol 2020; 110: 104539.
  22. Patel KS, Pandey PK, Martín-Ramos P, Corns WT, Varol S, Bhattacharya P, et al. A review on arsenic in the environment: contamination, mobility, sources, and exposure. RSC advances 2023; 13(13): 8803-21.
  23. Grau-Perez M, Navas-Acien A, Galan-Chilet I, Briongos-Figuero LS, Morchon-Simon D, Bermudez JD, et al. Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain. Environ Pollut 2018; 235: 948-55.
  24. Mahadik SR, Reddy ART, Choudhary K, Nama L, Jamdade MS, Singh S, et al. Arsenic induced cardiotoxicity: An approach for molecular markers, Epigenetic predictors and targets. Environ Toxicol Pharmacol 2024; 111: 104558.
  25. Zhang Q, Hou Y, Wang D, Xu Y, Wang H, Liu J, et al. Interactions of arsenic metabolism with arsenic exposure and individual factors on diabetes occurrence: Baseline findings from Arsenic and Non-Communicable disease cohort (AsNCD) in China. Environmental Pollution 2020; 265(Part A): 114968.
  26. Austin W. Throwing the baby out with the ashwater? Coal combustion residuals, water quality, and fetal health. [April 23 2021]. Available from: https://cpb-us-e1.wpmucdn.com/blogs.cornell.edu/dist/1/8608/files/2021/06/SCOWP21-Austin-Wes_SCWQ_Workshop___Coal_Ash_v2.pdf.
  27. Rudnai P, Csanády M, Borsanyi M, Kadar M, Masotti A. Arsenic in drinking water and pregnancy outcomes. an overview of the Hungarian findings (1985–2005). Arsenic: Sources, Environmental Impact, Toxicity and Human Health-A Medical Geology. 2013; 173: 180.
  28. Ahmad SA, Sayed M, Barua S, Khan MH, Faruquee M, Jalil A, et al. Arsenic in drinking water and pregnancy outcomes. Environ Health Perspect 2001; 109(6): 629-31.
  29. Rahman ML, Kile ML, Rodrigues EG, Valeri L, Raj A, Mazumdar M, et al. Prenatal arsenic exposure, child marriage, and pregnancy weight gain: associations with preterm birth in Bangladesh. Environ Int 2018; 112: 23-32.
  30. Banu SK, Stanley JA, Taylor RJ, Sivakumar KK, Arosh JA, Zeng L, et al. Sexually dimorphic impact of chromium accumulation on human placental oxidative stress and apoptosis. Toxicol Sci 2018; 161(2): 375-87.
  31. Wang H, Li J, Zhang X, Zhu P, Hao J-H, Tao F-B, et al. Maternal serum arsenic level during pregnancy is positively associated with adverse pregnant outcomes in a Chinese population. Toxicol Appl Pharmacol 2018; 356: 114-9.
  32. Almberg KS, Turyk ME, Jones RM, Rankin K, Freels S, Graber JM, et al. Arsenic in drinking water and adverse birth outcomes in Ohio. Environ Res 2017; 157: 52-9.
  33. Freire C, Amaya E, Gil F, Murcia M, LLop S, Casas M, et al. Placental metal concentrations and birth outcomes: The Environment and Childhood (INMA) project. Int J Hyg Environ Health 2019; 222(3): 468-78.
  34. Myers SL, Lobdell DT, Liu Z, Xia Y, Ren H, Li Y, et al. Maternal drinking water arsenic exposure and perinatal outcomes in inner Mongolia, China. J Epidemiol Community Health 2010; 64(4): 325-9.
  35. Wai KM, Mar O, Kosaka S, Umemura M, Watanabe C. Prenatal heavy metal exposure and adverse birth outcomes in Myanmar: a birth-cohort study. Int J Environ Res Public Health 2017; 14(11): 1339.
  36. Caldwell KL, Jones RL, Verdon CP, Jarrett JM, Caudill SP, Osterloh JD. Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004. J Expo Sci Environ Epidemiol 2009; 19(1): 59-68.
مجله دانشکده پزشکی اصفهان
دوره 42، شماره 796
هفته 4، بهمن
بهمن و اسفند 1403
صفحه 1137-1142

  • تاریخ دریافت 13 آبان 1403
  • تاریخ پذیرش 11 دی 1403