مجله دانشکده پزشکی اصفهان

مجله دانشکده پزشکی اصفهان

بیماری‌زایی، تشخیص و پیشگیری از انتقال ویروس لنفوتروپیک سلول T انسانی نوع 1 (HTLV- 1) از مادر به کودک: یک مطالعه‌ی مروری روایتی

نوع مقاله : مقاله مروری

نویسندگان
1 کارشناس ارشد مامایی، مربی،گروه پرستاری، دانشکده‌ی علوم پزشکی اسفراین، اسفراین، ایران
2 استادیار، گروه علوم پایه، دانشکده‌ی علوم پزشکی اسفراین، اسفراین، ایران
3 کارشناس ارشد پرستاری، مربی، گروه پرستاری، دانشکده‌ی علوم پزشکی اسفراین، اسفراین، ایران
چکیده
مقاله مروری




مقدمه: ویروس لنفوتروپیک سلول T انسانی نوع 1 (HTLV-1)، در حال حاضر هیچ واکسن و درمان قطعی ندارد. کشور ایران جزو مناطق اندمیک برای این عفونت می‌باشد. مطالعه‌ی حاضر با هدف شناخت دقیق HTLV-1 از جمله بیماری‌زایی، تشخیص، راه‌های پیشگیری از انتقال پری‌ناتال انجام شد.
روش‌ها: در این مطالعه‌ی مروری روایتی، جهت یافتن مقالات فارسی و انگلیسی با موضوع بیماری‌زایی، تشخیص و روش‌های پیشگیری از انتقال پری‌ناتال عفونت HTLV-1 در زنان باردار تا ماه مارس سال 2024، پایگاه‌های اطلاعاتی علمی SID،Magiran ،PubMed ،Scopus ، Google Scholar و Web of Science بررسی شدند.
یافته‌ها: HTLV-1 اغلب از طریق تماس سلول به سلول منتقل می‌شود. بر اساس مطالعات انجام شده، مهم‌ترین روش انتقال عمودی عفونت، شیردهی است. به همین دلیل استفاده از شیر منجمد، تغذیه انحصاری با شیرخشک، شیردهی کوتاه‌مدت (کمتر از 3 ماه)، پاستوریزه کردن شیر و استفاده از بانک‌های شیر به عنوان راهکارهای موثر پیشنهاد شده است. اما تغذیه انحصاری با شیر‌خشک بی‌خطرترین روش است. بار ویروسی بیش از 1 درصد در خون مادر و ابتلای مادر به لوسمی-لنفوم سلول T بزرگسالان در مطالعات مختلف باعث افزایش انتقال HTLV-1 از مادر به جنین شده است. بنابراین برای این مادران درمان ضد رتروویروسی در دوران بارداری، سزارین انتخابی قبل از شروع زایمان، پرهیز از شیردهی و شروع پروفیلاکسی با داروهای ضد رتروویروسی پس از تولد به مدت 6 هفته برای شیرخوار پیشنهاد شده است.
نتیجه‌گیری: با توجه به ارتباط HTLV-1 با بیماری‌های مختلف و ریسک بالای انتقال عمودی عفونت از طریق شیردهی، غربالگری زنان باردار در مناطق اندمیک و تدوین پروتکل پیشگیری از انتقال پری‌ناتال عفونت HTLV-1 توصیه می‌شود.

تازه های تحقیق

اشرف صابر: Google Scholar

کلیدواژه‌ها

موضوعات


عنوان مقاله English

Pathogenesis, Diagnosis and Prevention of Mother-to-Child Transmission of Human T-Cell Lymphotrophic Virus Type 1 (HTLV-1): a Narrative Review

نویسندگان English

Yasaman Saber 1
Bagher Moradi 2
Zahra Poshtchaman 3
1 MSc of Midwifery, Department of Nursing, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran
2 Assistant Professor, Department of Basic Sciences, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran
3 MSc of Nursing, Department of Nursing, Esfarayen Faculty of Medical Sciences, Esfarayen, Iran
چکیده English

Background: Human T-Cell Lymphotrophic Virus Type 1 (HTLV-1) currently has no definitive vaccine or treatment. Iran is an endemic area for this infection. The present study was carried out with the aim of knowing HTLV-1, including pathogenicity, diagnosis, and strategies to prevent perinatal transmission of the infection.
Methods: In this narrative review, Persian and English articles on the pathogenesis, diagnosis, and prevention of perinatal HTLV-1 transmission in pregnant women, published up to March 2024, were identified. Scientific databases including SID, Magiran, PubMed, Scopus, Google Scholar, and Web of Science were searched.
Findings: HTLV-1 is primarily transmitted through cell-to-cell contact. Studies indicate that breastfeeding is the most important route of vertical transmission. For this reason, the use of frozen milk, exclusive formula feeding, short-term breastfeeding (less than 3 months), milk pasteurization, and the use of milk banks have been suggested as effective preventive measures. exclusive formula feeding is considered the safest method. A maternal blood viral load exceeding 1% and maternal infection with adult T-cell leukemia-lymphoma have been associated with an increased risk of mother-to-child transmission. Therefore, for these mothers, suggested interventions include antiretroviral therapy during pregnancy, elective caesarean section before the onset of labor, avoidance of breastfeeding, and initiation of a 6-week postnatal antiretroviral prophylaxis regimen for the infant.
Conclusion: Given the association of HTLV-1 with various diseases and the high risk of vertical transmission through breastfeeding, it is recommended to screen pregnant women in endemic areas and to develop standardized protocols for the prevention of perinatal HTLV-1 transmission.

کلیدواژه‌ها English

Human T-lymphotropic virus 1
Infectious Disease Transmission
Vertical
Diagnosis
Pathogenesis
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دوره 43، شماره 836
هفته 4، آذر
آذر و دی 1404
صفحه 1390-1400

  • تاریخ دریافت 09 مرداد 1403
  • تاریخ پذیرش 10 آبان 1404