نوع مقاله : Original Article(s)
تازه های تحقیق
نازیلا پوستیان: Google Scholar, PubMed
ذبیح اله شاهمرادی: Google Scholar
ستایش سین دره: Google Scholar, PubMed
موضوعات
عنوان مقاله English
نویسندگان English
Background: The aim of the present study was to investigate the effectiveness of topical amphotericin gel on leishmaniasis cutaneous lesions by adding this drug to the standard treatment of leishmaniasis.
Methods: This randomized clinical trial was conducted on two groups of patients. The first group was treated with weekly intralesional injections of glucantime alone. The second group was treated weekly with intralesional injections of glucantime and 0.4% amphotericin topical gel daily.
Findings: The mean (standard deviation) age of 32 participants in the study was 33.4 (14.8) and 29 (72.5%) of them were men. 70% of patients in the glucantime alone group and 80% of patients in the amphotericin group showed complete cure. There was no significant difference between the two groups in terms of the outcome by examining changes in size and induration of the lesions (P>0.05). Results of repeated measures revealed that the effect of the course was significant for the change in the size of the lesions in the two drug groups (P=0.36).
Conclusion: The combination of amphotericin gel with the standard treatment of cutaneous leishmaniasis causes a slight increase in the effectiveness of the treatment, although this slight improvement was not significant in our study.
کلیدواژهها English
