مجله دانشکده پزشکی اصفهان

مجله دانشکده پزشکی اصفهان

بررسی افزایش اثربخشی نانوذرات تیتانیوم دی‌اکسید در سونوداینامیک‌تراپی: یک مرور نظام‌مند

نوع مقاله : مقاله مروری

نویسندگان
1 دانشجوی کارشناسی ارشد، گروه فیزیک پزشکی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
2 استادیار، گروه فیزیک پزشکی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
10.48305/jims.v44.i852.0241
چکیده
مقدمه: در سال‌های اخیر نانوذرات تیتانیوم دی‌اکسید (TiO2) به دلیل پایداری و غیر سمی بودن، پتانسیل مناسبی را برای استفاده در سونودینامیک‌تراپی نشان داده‌اند. با وجود این بررسی نظام‌مند مطالعات آزمایشگاهی نانوذرات TiO2 به عنوان حساس‌کننده‌ی صوتی تا لحظه‌ی نگارش این مقاله انجام نشده است. هدف از این مرور نظام‌مند، بررسی نقش فزاینده نانوذرات TiO2 در سونودینامیک‌تراپی و همچنین عوامل مؤثر در اثربخشی آنها بود.
روش‌ها: یک جستجوی جامع در پایگاه‌های PubMed، Scopus و Web of Science با کلیدواژه‌های تخصصی انجام شد. در مجموع، 14 مطالعه که معیارهای ورود را داشتند، انتخاب و فاکتور زنده‌ماندن سلولی برای سلول‌های تیمار شده با سونودینامیک‌تراپی با و بدون نانوذرات TiO2 در رده‌های مختلف سلول‌های سرطانی مورد بررسی قرار گرفت.
یافته‌ها: یافته‌ها نشان دادند که نانوذرات TiO₂به تنهایی سمیت اندکی دارند، اما در ترکیب با امواج فراصوت، باعث افزایش قابل توجه مرگ سلول‌های سرطانی می‌شوند. عواملی مانند شدت امواج، اندازه نانوذره و شکاف باند، نقش مؤثری در این هم‌افزایی ایفا می‌کنند.
نتیجه‌گیری: کاهش شکاف باند نانوذرات موجب افزایش تولید گونه‌های فعال اکسیژن و در نتیجه مرگ سلولی بیشتر می‌شود. همچنین پوشش‌هایی نظیر پلی‌اتیلن‌گلیکول و غشای سلول سرطانی، پایداری و هدف‌گیری نانوذرات را بهبود می‌بخشند. شدت امواج فراصوت در حد بهینه موجب بیشترین اثربخشی در حضور نانوذرات می‌شود. مطالعات آزمایشگاهی نشان داده‌اند که نانوذرات TiO2 حساس‌کننده‌های صوتی مؤثری برای سونوداینامیک‌تراپی در برابر سلول‌های سرطانی هستند و با انتخاب شرایط بهینه برای نانوذرات TiO2 و شدت امواج فراصوت می‌توان اثربخشی درمان را افزایش و عوارض جانبی را کاهش داد.

تازه های تحقیق

علی سالاروند: Google Scholar, PubMed

جواد گرشاد: Google Scholar, PubMed

مهسا منصوریان: Google Scholar, PubMed

کلیدواژه‌ها
موضوعات

عنوان مقاله English

TiO2 nanoparticles as a sonosensitizer for sonodynamic therapy: A Systematic Review of in Vitro Studies

نویسندگان English

Ali Salarvand 1
Javad Garshad 1
Mahsa Mansourian 2
1 MSc Student, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences Introduction, Isfahan, Iran
چکیده English

Introduction: In recent years, titanium dioxide (TiO2) nanoparticles have demonstrated suitable potential for use in sonodynamic therapy due to their stability and non-toxicity. Despite this, systematic in vitro studies are rare. An aim of this systematic review is to investigate the increasing role of TiO2 nanoparticles in sonodynamic therapy as well as factors contributing to their efficacy.
Methods: A comprehensive literature search was conducted on Scopus, Web of science, and PubMed. A total of 14 studies that met the inclusion criteria were selected and cell viability was examined under sonodynamic therapy with and without TiO2 nanoparticles in different cell lines.
Results: The findings indicated that TiO₂ nanoparticles have minimal intrinsic toxicity but significantly enhance cancer cell death when combined with ultrasound waves. Factors such as ultrasound intensity, the size, and the band gap of TiO2 nanoparticles play a critical role in this synergistic effect.
Discussion: A reduced band gap in TiO₂ nanoparticles leads to increased generation of reactive oxygen species (ROS), thereby enhancing cell death. Moreover, surface coatings such as polyethylene glycol (PEG) and cancer cell membranes improve the stability, dispersion, and targeting capability of the nanoparticles. Optimal ultrasound intensity further maximizes therapeutic efficiency.
Conclusion: In vitro studies suggest that TiO₂ nanoparticles are effective sonosensitizers for SDT against cancer cells and optimizing nanoparticle characteristics and ultrasound parameters can enhance treatment efficacy while minimizing side effects on healthy tissues.

کلیدواژه‌ها English

Titanium dioxide
Nanoparticles
Ultrasonic therapy
Neoplasms
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دوره 44، شماره 852
هفته 4، فروردین
فروردین و اردیبهشت 1405
صفحه 241-252

  • تاریخ دریافت 29 دی 1403
  • تاریخ پذیرش 02 اسفند 1404