نوع مقاله : Original Article(s)
تازه های تحقیق
رضا کاظمی: PubMed, Google Scholar
موضوعات
عنوان مقاله English
نویسندگان English
Background: Distal ureteral stones <10 mm are a frequent cause of emergency urological
visits. Medical expulsive therapy (MET) with alpha-blockers such as tamsulosin is commonly
used, yet adjunctive anti-inflammatory agents may enhance efficacy. This study evaluated
whether adding intramuscular dexamethasone to oral tamsulosin improves stone expulsion
outcomes compared to tamsulosin monotherapy.
Materials and Methods: In this double-blind, parallel-group randomized controlled trial,
110 adults with symptomatic distal ureteral stones ≤10 mm confirmed by non-contrast CT
were randomized 1:1 to receive either oral tamsulosin 0.4 mg daily plus intramuscular
dexamethasone 8 mg weekly (intervention group, n=55) or oral tamsulosin plus
intramuscular normal saline placebo (control group, n=55). Treatment continued for up to 14
days or until stone passage. The primary outcome was stone expulsion rate by day 14.
Secondary outcomes included time to expulsion, analgesic use (diclofenac suppositories),
emergency department visits, work days lost, and need for lithotripsy.
Conclusion: Weekly intramuscular dexamethasone combined with daily oral tamsulosin
significantly improved stone expulsion rate, reduced analgesic use, and minimized work
absence compared to tamsulosin alone, supporting its role as an enhanced MET strategy for
distal ureteral stones <10 mm.
کلیدواژهها English
