نوع مقاله : مقاله های پژوهشی
تازه های تحقیق
مهدی کیائی: Google Scholar , PubMed
مهدی مارزلو: Google Scholar , PubMed
حامد علیزاده پهلوانی: Google Scholar , PubMed
ندا آقایی بهمن بگلو: Google Scholar , PubMed
عنوان مقاله English
نویسندگان English
Background: The aim of the present study is to investigate the combined effect of high- and moderate-intensity aerobic training on the sirtuin-related mitochondrial unfolded protein response (UPRmt) in the left ventricle of aged rats.
Methods: The present experimental-basic study included 12 20-month-old male Wistar rats with an average weight of 400±30 g. The inclusion criteria were rats older than 20 months of age. The aged rats were randomly divided into a combined high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) group (six rats) and a control group (six rats). Combined HIIT and MICT training was performed for eight weeks, five sessions per week. The HIIT program was performed with high-intensity intervals (85-95% of maximum speed) and rest (40-55%), and the MICT program was performed with an intensity of 40-70%.
Findings: After eight weeks of combined aerobic training, the levels of sirtuin 3 (p=0.001) and FOXO3a (p=0.001) proteins significantly increased compared to the control group. However, after eight weeks of combined aerobic training, the levels of sirtuin 7 (p=0.25) proteins did not change significantly; however, the levels of NRF1 (p=0.007) proteins showed a significant increase. The levels of SOD (p=0.02) and catalase (p=0.001) in the combined aerobic training group showed a significant increase compared to the control group.
Conclusion: The increase in the levels of sirtuin 3, FOXO3A, NRF1, SOD and catalase emphasizes the importance of aerobic exercise for elderly people for cellular health and resistance to oxidative stress through UPRmt.
کلیدواژهها English
