مجله دانشکده پزشکی اصفهان

مجله دانشکده پزشکی اصفهان

از اسید استیک تا اکسازولون: مروری مقایسه‌ای بر مدل‌های القای شیمیایی کولیت اولسراتیو

نوع مقاله : Review Article

نویسندگان
1 کارشناس، گروه علوم آزمایشگاهی، دانشکده‌ی پیراپزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران
2 استاد، گروه علوم آزمایشگاهی، دانشکده‌ی پیراپزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران
10.48305/jims.v44.i864.0889
چکیده
مقدمه: کولیت اولسراتیو، یک بیماری التهابی مزمن روده بزرگ است که شیوع بالایی در جوانان دارد. ارایه‌ی راه‌های پیشگیری و درمان نیاز به مطالعات انسانی و بکارگیری مدل‌های حیوانی دارد. هدف این مطالعه‌ی مروری، بررسی روش‌های اصلی‌ القا شیمیایی کولیت در مدل‌های حیوانی می‌باشد.
روش‌ها: PubMed و Google Scholar با کلمات کلیدی «کولیت اولسراتیو» و «مدل حیوانی» و القاء شیمیایی مورد جستجو قرار گرفت. اطلاعات مربوط به مواد شیمیایی اصلی، حیوانات مورد استفاده و ویژگی بالینی هر روش جمع‌آوری گردید.
یافته‌ها: نتایج نشان داد که اسید استیک، سدیم دکستران سولفات، تری‌نیترو بنزوییک اسید و اگزازولون بیشترین کاربرد در مدل‌های القا شیمیایی کولیت دارند. هر روش ویژگی‌های آسیب‌زایی خاص خود دارد و با جنبه‌ای از بیماری کولیت در انسان انطباق دارد. موش‌های صحرایی و موش‌های کوچک بیشترین کاربرد را در ایجاد مدل‌های کولیت دارند. در کنار آنها از خوک و سگ با دستگاه گوارش شبیه انسان نیز استفاده می‌گردد. عوامل متعددی مانند دوز و غلظت ماده‌ی شیمیایی، دفعات تجویز، جنسیت، سن و نژاد حیوان بر نتایج مطالعات اثرگذار هستند.
نتیجه‌گیری: مدل‌های حیوانی کولیت اولسراتیو می‌توانند به شناخت آسیب‌شناسی، تشخیص و درمان کولیت اولسراتیو کمک کنند. با توجه به چندگانگی نحوه‌ی ایجاد بیماری کولیت در انسان، مدل‌های شیمیایی می‌تواند به شخصی‌سازی درمان بیماران کولیت کمک کند.

تازه های تحقیق

زهرا نکوئی شهرکی:  Google Scholar

نفیسه عبدالهی:  Google Scholar

فاطمه صحرائیان:  Google Scholar

محمدعلی تخشید:  Google Scholar ,PubMed

کلیدواژه‌ها
موضوعات

عنوان مقاله English

From Acetic Acid to Oxazolone: A Comparative Review of Chemically Induced Ulcerative Colitis Models

نویسندگان English

Zhra Nekoei Shahraki 1
Nafise َAbdolahii 1
Fatemeh Ssahraeian 1
Mohammad Ali Takhshid 2
1 BS, Department of Laboratory Sciences, School of Paramedical Sciences, Shiraz, Iran
2 Professor, Department of Laboratory Sciences, School of Paramedical Sciences, Shiraz, Iran
چکیده English


Background: Ulcerative colitis is a chronic inflammatory disease with a high prevalence in young adults. Developing strategies for prevention and treatment requires both clinical studies and the use of animal models. This review aimed to examine the main methods of chemically induced colitis in animal models.
Methods: PubMed and Google Scholar were searched using the keywords “ulcerative colitis”, “animal model”, and “chemical induction.” Data on the primary chemical agents, the animal species used, and the clinical features of each method were collected.
Findings: The findings indicate that acetic acid, dextran sodium sulphate, trinitrobenzene sulfonic acid, and oxazolone are the most commonly used agents for inducing colitis. Each method has its own pathogenic features and corresponds to specific aspects of ulcerative colitis in humans. Rats and mice are the most frequently used species for establishing colitis models. Pigs and dogs—due to gastrointestinal similarities to humans—are also employed. Several factors, including the dose and concentration of the chemical agent, frequency of administration, as well as the sex, age, and strain of the animals, significantly influence study outcomes.
Conclusion: Animal models of ulcerative colitis can contribute to understanding the pathogenesis, diagnosis, and treatment of the disease. Given the heterogeneous nature of ulcerative colitis in humans, chemically induced models may also support the development of personalized therapeutic approaches for patients.

کلیدواژه‌ها English

Ulcerative colitis
Disease Models
Chemically induced
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دوره 44، شماره 864
هفته 4، تیر
خرداد و تیر 1405
صفحه 889-897

  • تاریخ دریافت 02 مهر 1404
  • تاریخ پذیرش 21 تیر 1405