استفاده‌ی سرپایی از داروهای گیاهی در آمادگی سرویکس و شروع زایمان: یک مرور سیستماتیک و متاآنالیز

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه مامایی، کمیتهی تحقیقات دانشجویی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

2 استادیار، مرکز تحقیقات مراقبتهای پرستاری و مامایی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

3 استادیار، گروه آمار زیستی، دانشکده ی بهداشت، دانشگاه علوم پزشکی مشهد، مشهد، ایران

چکیده

مقدمه: در سال‌‌های اخیر، استفاده‌ی سرپایی از داروهای گیاهی جهت آماده‌سازی سرویکس و القای زایمان به دلیل کاهش هزینه‌ها و افزایش رضایت بیمار، مورد توجه قرار گرفته و با توجه به عوارض داروهای شیمیایی، تمایل بیماران به استفاده از داروهای گیاهی نیز افزایش یافته است. پژوهش حاضر با هدف ارزیابی و جمع‌بندی نتایج کارآزمایی‌های بالینی انجام شده در جهان در ارتباط با استفاده‌ی سرپایی از داروهای گیاهی در آمادگی سرویکس و القای زایمان انجام شد.
روش‌ها: کارآزمایی‌های بالینی در ارتباط با استفاده‌ی سرپایی از داروهای گیاهی در آمادگی سرویکس و القای زایمان، بدون محدودیت زمانی و زبانی از پایگاه‌های اطلاعاتی Magiran، Scientific Information Database (SID)، ScienceDirect، Cochrane Library، PubMed، Scopus و Google Scholar تا تاریخ 20 آوریل سال 2021 مورد جستجو قرار گرفت و داده‌ها در نرم‌افزار Stata تجزیه و تحلیل گردید.
یافتهها: 16 مقاله که دارای معیارهای ورود به تحقیق بودند، بررسی شد. انجام متاآنالیز تنها بر روی روغن کرچک و خرما امکان‌پذیر بود. بر اساس یافته‌ها، بخت شروع خودبه‌خودی دردهای زایمان در گروه روغن کرچک، 760/5 برابر و در گروه خرما، 205/2 برابر گروه شاهد بود. افزایش نمره‌ی Bishop در گروه روغن کرچک نیز 2 برابر گروه شاهد گزارش شد. نتایج نمودار قیفی و آزمون Egger، سوگیری انتشار را رد کرد (710/0 = P). اسپند، خاکشیر، بابونه و زعفران هم در آمادگی سرویکس و شروع زایمان مؤثر بودند.گل مغربی بر نمره‌ی Bishop اثر داشت، اما تأثیری در شروع خودبه‌خودی زایمان نشان نداد. برگ تمشک قرمز در شروع خودبه‌خودی زایمان مؤثر نبود.
نتیجه‌گیری: از بین گیاهان ذکر شده، روغن کرچک و خرما دارای شواهد بیشتری در آماده‌سازی سرویکس و شروع زایمان می‌باشند. انجام مطالعات بیشتر با متدولوژی قوی‌تر ضروری به نظر می‌رسد.



 


 

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Outpatient Herbal Drugs on Cervical Ripening and Onset of Labor: A Systematic Review and Meta-Analysis

نویسندگان [English]

  • Maryam Ghasemi . 1
  • Samira Ebrahimzadeh-Zagami . 2
  • Vahid Ghavami . 3
1 1- MSc Student, Department of Midwifery, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

Background: In recent years, outpatient cervical ripening and induction of labor has been considered because of
reduced costs and increased patient satisfaction. Moreover, due to the side effects of chemical drugs, the
tendency of patients for use of herbal medicines has increased. The aim of this study was to evaluate and
summarize the results of clinical trials about outpatient herbal medicines in cervical ripening and onset of labor.
Methods: Clinical trials related to outpatient use of herbs in cervical ripening and onset of labor, were searched
without time and language restrictions in Scopus, Pubmed, Cochrane library, Science direct, Scientific Information
Database (SID), Magiran, and Google Scholar search engines until March 30, 2021. Data analysis was performed
using STATA software.
Findings: 16 articles that met the inclusion criteria were reviewed. Meta-analysis was only possible on castor oil
and date fruit. The chance of spontaneous onset of labor in was 5.760 and 2.205 times the castor oil and date
groups, respectively. Moreover, the increase in bishop score in castor oil group was 2 times higher than the
control group. The results of funnel plot and Egger test found no evidence of publication bias (P = 0.710).
Peganum, Sisymbrium, chamomile, and saffron were effective in cervical ripening and onset of labor. Evening
primrose was effective on Bishop score, but had no effect on spontaneous onset of labor. Red raspberry leaves
were not effective in spontaneous onset of labor.
Conclusion: Among the mentioned plants, castor oil and date fruit have more evidence in cervical ripening and
onset of labor. Further studies with stronger methodologies are needed.

کلیدواژه‌ها [English]

  • Labor onset
  • Induction of labor
  • Cervical ripening
  • Outpatient
  • Herbal medicine 
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