Background: Nosocomial infections are one of the most important medical problems in developed and under developing countries which cause the spread of infections diseases in society. Pseudomonas aeroginosa is one of the most important causes of hospital infections, especially in wounds from operated patients. Increase in antibiotic-resistance of pseudomonas aeroginosa cause a lot of problems for patients and in some cases lead to septicemia and death of patients. The aim of this study is to isolate and determine the drug resistance pattern of indigenous pseudomonas leading to cutaneous infections of patients in Alzahra hospital. Methods: In this study 770 samples were obtained from cutaneous wounds of patients hospitalized in Azahra hospital. Biochemical tests were used for identification of Pseudomonas aeroginosa. Antibacterial susceptibility test for antibiotics amikacin, cephtazidin, ciprofloxacin, tasocin, imipinim was performed using disk diffusion (Kirby- Buer) methods. Findings: Among 770 patients, 56 patients (7.3%) showed cutaneous infection caused by pseudomonas aeroginosa. Antibiotic resistance pattern showed that 82. 14% samples were resistant to ceftriaxone and for amikacin 57.14%, ceftazidime 53.57%, ciprofloxacin 42.85%, tazocin 39.28%, imipenem 14.28% respectively. Conclusion: These results indicate the necessity of culturing and antibiogram tests before treatment of bacterial cutaneous infections. Antibiotic resistance- patterns can be very helpful in choosing the appropriate drug. Also in the first phase, it cold be considered for treatment of the disease. Key words: Nosocomial infections, Skin infection, Pseudomonas aeroginosa, Drug resistance, Antibiotic.