Journal of Isfahan Medical School

Journal of Isfahan Medical School

Aspirin resistance status as determined by urinary thromboxane B2 (TXB2) level in patients with ischemic heart disease and its relationship with Severity of coronary artery disease

Document Type : Original Article(s)

Authors
Naghmeh Ziaie 1
Masoomeh Sadeghi 2
Arash akhlaghi 3
Omid Pirhaji 4
Majid Yaran 5
Masood Pourmoghadas 6
1 Resident, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Associate Professor of Cardiology, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
3 Fellowship of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran.
4 Medical Student, Isfahan University of Medical Sciences, Isfahan, Iran.
5 PhD, Isfahan University of Medical Sciences, Isfahan, Iran.
6 Professor of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract
Background: Coronary artery disease (CAD) and myocardial infarction are the most common cause of mortality and morbidity all over the world.. Aspirin resistance is an important part of therapeutic failure in patients who experience several atherosclerotic events despite aspirin therapy.Different stud-ies have reported aspirin resistance between 5-45% all over the world. According to different re-sponses to aspirin therapy in different countries and lack of adequate studies on aspirin resistance in Iran, this study was designed for invitro evaluation of aspirin resistance in Iranian patients .
Methods: 170 patients with documented coronary artery stenosis were enrolled in this cross-sectional prospective study. 2 cc urine samples were obtained from all the subjects.Then a questionnaire includ-ing questions about ischemic heart disease risk factors (hypertension, diabetes, hyperlipidemia, obesity and smoking) was completed for each patient. Thromboxane B2 level in urine was measured two times for each patient via ELISA method. Data were analyzed via SPSS 16. with General Linear Model (Univariate).Gensini modified was used for assessment of severity of coronary arteries in-volvement (Coronary angiography score).
Finding: 75.3% of studied patients were aspirin resistant. There was significant relationship between angiography score and aspirin resistance (Pvalue
Keywords
Aspirin resistance
Thromboxane B2 level
Coronary artery disease (CAD)
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Journal of Isfahan Medical School
Volume 28, Issue 116 - Serial Number 116
September and October 2011
Pages 1008-1015

  • Receive Date 29 January 2011
  • Accept Date 06 April 2022