ارزیابی تغییرات اولیه در فلوی دیاستولیک دریچه‌ی میترال و یافته‎های

نوع مقاله : Original Article(s)

نویسندگان

1 دانشیار، گروه داخلی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران.

2 دستیار، گروه داخلی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران.

3 استادیار، گروه داخلی- قلب، دانشکده‌ی پزشکی،دانشگاه علوم پزشکی کردستان، سنندج، ایران.

چکیده

مقدمه: در مطالعات تجربی و بالینی، پس از انجام Percutanouse coronary angioplasty (PCI)، چه در فاز اولیه و چه در فاز دیررس، بهبودی عملکرد دیاستولی Left ventricle (LV) اتفاق می‌افتد. از آن جا که فلوی دیاستولی میترال، که توسط Pulse wave (PW) اندازه گیری می‌شود، محدودیت‌هایی دارد، به تازگی از Tissue doppler imaging (TDI) که یک روش ساده، حساس و ارزان قیمت می‌باشد، برای ارزیابی عملکرد دیاستولی بطن چپ استفاده می‌شود که وابسته به عوامل مخدوش کننده‌ای مثل تعداد ضربان قلب نیست. روش‌ها: 40 نفر از بیماران کاندید آنژیوپلاستی به علت تنگی شدید Left anterior desending (LAD) انتخاب شدند و همگی تحت آنژیوپلاستی و گذاشتن Stent قرار گرفتند. همه‌ی بیماران قبل از آنژیوپلاستی و یک ماه پس از آن تحت اکوکاردیوگرافی قرار گرفتند. پارامترهای داپلر معمولی شامل E wave deceleration time، A velocity و E velocity و پارامترهای TDI شامل Aa velocity، Ea velocity و Sa velocity اندازه گیری شد. داده‌های قبل و بعد از PCI با هم مقایسه شدند. یافته‌ها: پس از PCI در داپلر معمولی فقط E wave deceleration time به صورت معنی‌دار بهبود یافت ولی پارامترهای دیگر شامل A velocity و E velocity تغییر معنی‌دار نداشت. از بین پارامترهای TDI نیز Aa velocity و Ea velocity در ناحیه‌ی سپتوم به طور معنی‌داری بهبود یافت ولی Sa velocity ناحیه‌ی سپتوم با وجود افزایش، از نظر آماری معنی‌دار نبود. بهبود مشخص در Ea velocity در ناحیه‌ی لترال اتفاق افتاد؛ Sa velocity و Aa velocity بهبود یافت ولی از نظر آماری معنی‌دار نبود. نتیجه‌گیری: در بیماران مبتلا به بیماری عروق کرونر (Coronary artery disease) عملکرد سیستولی و دیاستولی مختل می‌شود که به راحتی می‌توان آن را توسط TDI تشخیص داد؛ اگر چه اختلال عملکرد سیستولی پس از PCI باقی می‌ماند، ولی عملکرد دیاستولی به صورت مشخص بعد از آنژیوپلاستی بهبود می‌یابد. مطالعه‌ی ما نشان داد که پس از PCI عملکرد دیاستولی بطن چپ بهبود می‌یابد و این بهبودی در طول زمان اتفاق می‌افتد. بر خلاف مطالعات قبلی، این مطالعه نشان داد که Aa velocity یک ماه پس از رواسکولاریزاسیون به طور معنی‌داری بهبود می‌یابد. واژگان کلیدی: آنژیوپلاستی، کرونر، اکوکاردیوگرافی داپلر، Tissue doppler imaging .

کلیدواژه‌ها


عنوان مقاله [English]

Evaluation of Early Alterations in Transmitral Diastolic Flow and Tissue Doppler Findings of the Septal and Lattral Segments of Left Ventricles in Early Period after Coronary Angioplasty

نویسندگان [English]

  • Hasan Shemirani 1
  • Kajhal Karimi 2
  • Reza Madadi 3
1 Associate Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Resident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
3 Assistant Professor, Department of Internal Medicine and Cardiology, School of Medicine, Kordestan University of Medical Sciences, Sanandaj, Iran.
چکیده [English]

Background: We aimed to evaluate subepicardial and subendocardial left ventricular (LV) functions in patients with single coronary artery lesion at early stage after percutaneous coronary intervention (PCI). Methods: Patients with left anterior descending (LAD) lesion (n = 40) were evaluated. Patients un-derwent PCI and at least one coronary stent was placed. After PCI, the pulsed-wave tissue doppler im-aging (pw-TDI) parameters taken from subepicardial and subepicardial layers were compared among the them. Finding: The systolic and diastolic pw-TDI parameters were apparently different between the patient after PCI, while the systolic pw-TDI parameters did not change. The diastolic pw-TDI parameters taken from both subepicardial (circumferential contraction) and subendocardial layers (longitudinal contraction) improved after PCI. After PCI, it was shown that while Ea velocity (P = 0.012) taken from the subendocardial layer increased, IVRa velocity (P < 0.001) taken from the subepicardial layer decreased. Conclusion: In our study, left ventricular, left atrium, and aortic valve diameter increase in patients with coronary artery disease. The systolic and diastolic functions were impaired at subendocardial and subepicardial layers. These dysfunctions can be easily presented with pw-TDI. Although systolic dys-function persists, diastolic dysfunction improves at early stage after PCI. Key words: Angioplasty, Percutaneous Coronary, Echocardiography, Doppler, Tissue doppler imag-ing.

کلیدواژه‌ها [English]

  • Angioplasty
  • Percutaneous Coronary
  • Echocardiography
  • Doppler
  • Tissue doppler imaging
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