نوع مقاله : Original Article(s)
1 استادیار، گروه عفونی، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
2 دانشجوی پزشکی، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران.
3 مرکز تحقیقات بیماریهای کلیهی اصفهان، استادیار، گروه نفرولوژی، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
عنوان مقاله [English]
Background: The risk of increasing active tuberculosis is a significant health problem among patients receiving hemodialysis. Also prophylactic therapy against tuberculin in these patients is important to have a successful transplantation. The tuberculin skin test (TST) is used to detect tuberculosis infection, but uremia in these patients may lead to coetaneous anergy that decrease the accuracy of the test. The aim of study was to identify the TST reactivity and frequency of booster phenomenon in 3-step TST in under hemodialysis patients.Methods: A total of 74 patients in Alzahra and Zahraye Marziye hemodialysis center in Isfahan were prospectively tested. To determine the frequency of booster effect, patients with less than 10 mm indurations were given additional TST one and four weeks after the initial test.Finding: Totally, 12 (16.2%) of 74 patients showed a positive tuberculin reaction (≥ 10 mm) on the initial test. Positive TST in 8 patients (10.8%) was added after the second test and in 6 patients (8.1%) after the third test. The booster phenomenon was detected in 18.9% of the patients. There was a significant correlation between TST positivity and anemia. There was no influence of age, gender, serum albumin level, urea reduction ratio and KT/V (P > 0.05).Conclusion: According to the results and the necessity of diagnosis of tuberculin in hemodialysis patients, our study support 3-step tuberculin skin testing in hemodialysis patients. As TST is easy and inexpensive, it seems to be useful for kidney transplant candidates.Keywords: Hemodialysis, Booster effect, Tuberculin skin test, Tuberculosis.