Background: Several important groups of diseases (malignant disease) of unknown cause and treatment are uncertain when the prevalence and spatial distribution maps are plotted important differences from one point to another point are observed. This article is the result of research in Isfahan province using medical information and relying on geological phenomena Geogenic open (Map distribution of plumb in the province) was done and plans to establish meaningful communication between some diseases (Case Study: Malignant Disease) and accumulation of heavy metals in the earth (case study: Plumb), compared to the spatial distribution of malignant diseases associated with the disease attempt to plumb in Isfahan province.Methods: In this study, all the statistics recorded by malignant disease in Isfahan province during 1386 to 1388 was prepared. Statistics collected for the preparation of spatial distribution maps were used with malignant disease, then map the distribution of plumb Isfahan Province, in order to adapt the frequency and plumb concentrations associated with the poll frequency of malignant disease of the Geological Survey and Mineral Exploration country was prepared and used at the end of Statistics concentration of plumb in three areas: (agricultural land, non agricultural, urban and industrial ), in order to Informed concentrations of plumb to ensure the distribution of plumb in the province of Agriculture Province were made using the software GIS (geographic information system or the software that can by it, by entering a little data Places in the mapping information table Diagram paid) and enter information about diseases in the table Province Province of malignant disease spatial distribution was mapped and distribution of plumb in the province were compared.Finding: Results from the study can be stated as follows. Space with tracing the distribution of ten common malignant disease in the province, which was scattered three types of malignant diseases including: malignant skin diseases, blood diseases and malignant breast disease malignant based on the distribution of plumb in the points is an important part of this type of disease Isfahan province disabled malignant there is plumb in the points.Conclusion: Mapping the spatial distribution of ten common malignant disease in Isfahan province showed typical element of the relationship between lead and three types of malignant disease in Isfahan.