نوع مقاله : مقاله های پژوهشی
نویسندگان
1 استاد، گروه گوش و حلق وبینی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
2 دانشیار، گروه گوش و حلق وبینی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
3 دانشجوی پزشکی، دانشکده‌ی پزشکی و کمیته‌ی تحقیقات دانشجویی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
4 دانشیار گروه پاتولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
چکیده
کلیدواژه‌ها
عنوان مقاله [English]
نویسندگان [English]
Background: Otomycosis is the superficial mycotic infection of the external ear canal which occurs as acute, subacute and chronic infection. It is the cause of 6.5% to 12.5% of external otitis. More than 62 species and 28 genera of fungi have been identified in patients with otomycosis among which the most common organisms are Aspergillus Niger and Candida Albicans. Recommended topical medications include steroids, anti-septic, acidic solutions, antifungal, and drying agents. The commonly recommended antifungal drugs are clotrimazole, amphotericin B, otosporin, and tolnaftate. This study aimed to identify two genera of fungus, and compare the efficacy of the treatment of clotrimazole and tolnaftate and the recurrence rate after the treatment.Methods: This was a clinical trial study conducted on 54 patients diagnosed with otomycosis (based on culture and smear with identification of the fungus genus and species). We compared the effect of clotrimazole and tolnaftate on the treatment and its recurrence on different types of fungus.Findings: After finishing the treatment course, 22 patients were improved in clotrimazole (81.5%); however, in the tolnaftate group, there were 21 improved patients (77.8%). Besides, Chi-square test showed no significant difference between the two groups (P = 0.99). Furthermore, out of 43 patients who have improved after the treatment, recurrence was seen in 15 of them (34.9%). Disease recurrence cases in the group treated with clotrimazole and tolnaftate were 8 and 7 patients respectively (36.4% vs. 33.3%). Although, the frequency distribution of disease recurrence was lower in the tolnaftate group, according to chi-square test, there was no significant difference between the two groups (P = 0.99).Conclusion: According to the results of this study and its comparison with other studies, both clotrimazole and tolnaftate had an appropriate impact on treating fungal infections of the ear. Given the non-improvement and recurrence cases, we should attempt to detect other therapeutic methods of otomycosis, and currently aspects such as financial and economic issues should be taken into account in choosing to use either of the drugs.
کلیدواژه‌ها [English]
)