بررسی اثر دریافت مکمل کرستین بر عملکرد اندوتلیال، استرس اکسیداتیو، عملکرد ورزشی، شاخص‌های التهابی و آسیب عضلانی در ورزشکاران

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی دکترای تخصصی تغذیه، کمیته‌ی تحقیقات دانشجویی، گروه تغذیه‌ی جامعه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 استادیار، مرکز تحقیقات امنیت غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 کارشناس، گروه تغذیه‌ی جامعه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: در دهه‌های اخیر ورزشکاران به استفاده از مکمل‌های ورزشی به منظور افزایش قدرت عضلانی و استقامت ورزشی روی آورده‌اند. کرستین یکی از فلاونوییدهای طبیعی می‌باشد که به خاطر مزایای گسترده ‌ای که بر سلامتی دارد، مورد توجه قرار گرفته است. هدف از بررسی حاضر، مروری بر مطالعات صورت گرفته در زمینه‌ی بررسی اثر دریافت مکمل کرستین بر عملکرد اندوتلیال، استرس اکسیداتیو، عملکرد ورزشی، شاخص‌های التهابی و آسیب عضلانی در ورزشکاران بود.روش‌ها: به این منظور از جستجو در PubMed،  Scopusو ISI بین سال‌های 1997 تا 2011 با کلید واژه‌های Quercetin، Endothelial function، Oxidative stress، Performance،Inflammation ، Muscle damage index و Athletes استفاده شد. تمام مطالعات حیوانی و انسانی با طراحی کارآزمایی بالینی در این بررسی وارد شدند.یافته‌ها: نتایج برخی مطالعات حاکی از اثرات مفید مصرف مکمل کرستین بر عملکرد ورزشی در ورزشکاران بود. کرستین از طریق افزایش بیوژنز میتوکندری عضلات موجب افزایش VO2max و تأخیر در زمان خستگی ناشی از ورزش می‌شود. همچنین به واسطه‌ی مهار NADPH اکسیداز و فعال شدن eNOS، غلظت اکسید نیتریک افزایش و غلظت اندوتلین 1 کاهش می‌یابد و در نتیجه منجر به بهبود عملکرد اندوتلیال می‌شود. اما در برخی مطالعات مکمل کرستین اثر معنی‌داری بر بهبود وضعیت اکسیداتیو بدن نشان نداد.نتیجه‌گیری: در بیشتر مطالعات اثرات مفید کرستین در نمونه‌های غیر حرفه‌ای تأیید شده است، ولی با توجه به کم بودن مطالعات انسانی و نتایج ضد و نقیض برخی مطالعات، نیاز به مطالعات انسانی بیشتری در این زمینه است.

کلیدواژه‌ها


عنوان مقاله [English]

The Effects of Quercetin Supplementation on Endothelial Function, Oxidative Stress, Athletic Performance, Inflammatory Biomarkers and Muscle Damage Indices in Athletes

نویسندگان [English]

  • Gholamreza Askari 1
  • Reza Ghiasvand 2
  • Maryam Hajishafiee 3
  • Fahime Akbari 3
1 PhD Student, Student Research Committee, Department of Society Nutrition, School of Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Society Nutrition, School of Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: During recent decades, a strong tendency to consume supplements in order to enhance muscular power and exercise endurance has grown among athletes. Quercetin is one of the flavonoid substances that received great attention due to its known benefits to health. The purpose of this study was to determine the effects of quercetin supplement intake on the above mentioned variables.Methods: An online search has been performed using the keywords "quercetin, endothelial function, oxidative stress, performance, inflammation, muscle damage and athletes" in ISI, Scopus and PubMed journals published during 1997-2011. All clinical trials were included in this study.Findings: A number of studies have suggested the positive effects of quercetin intake on exercise performance in athletes. These studies suggested quercetin to increase the muscles' mitochondrial biogenesis by boosting VO2max and thus delay fatigue during exercise. In addition, it did not allow NADPH oxidase, activated eNOS, augmented nitrate oxide and decreased endothelin-1 concentration, and resulted in an improvement of endothelial function. However, some other did not confirm the significant improvement of oxidative status.Conclusion: Most of the studies have acknowledged the positive effects of quercetin supplement intake in untrained athletes. However, due to the small number of investigations conducted on humans and the contradictory results, more controlled clinical trials are needed.

کلیدواژه‌ها [English]

  • Quercetin
  • Endothelial function
  • Oxidative Stress
  • Exercise performance
  • Inflammatory markers
  • Muscle damage indices
  • Athletes
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