پره‌اکلامپسی از دیدگاه سلولی و ملکولی

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه زیست‌شناسی، دانشکده‌ی علوم، دانشگاه اصفهان، اصفهان، ایران

2 استادیار، گروه زیست‌شناسی، دانشکده‌ی علوم، دانشگاه اصفهان، اصفهان، ایران

3 دانشیار، گروه زنان و زایمان، دانشکده‌ی پزشکی،دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: پره‌اکلامپسی یک اختلال سیستمیک مختص به دوران بارداری است که در 3-5 درصد از بارداری‌ها رخ می‌دهد و عامل اصلی مرگ و میر مادر و نوزاد در سطح جهان، به شمار می‌رود. با وجود دهه‌ها تحقیق و پژوهش، علت این بیماری ناشناخته باقی مانده است و تشخیص آن، قبل از بروز علایم، امکان‌پذیر نمی‌باشد.این مقاله‌ی مروری جنبه‌های مختلف پره‌اکلامپسی را به منظور تشریح پاتوفیزیولوژی آن، بررسی کرد.روش‌ها: مطالعه‌ی کنونی با استفاده از پایگاه‌های اطلاعاتی Ebsco، OVID، Pubmed،  Elsevierو NCBI، به بررسی 96 مقاله منتشرشده پرداخت تا جنبه‌های مختلف پره‌اکلامپسی را شامل سبب‌شناسی، ژنتیک، پروتئومیکس و متابولومیکس تشریح کند.یافته‌ها: بر اساس مطالعات منتشرشده، نقص عملکرد اندوتلیالی و استرس اکسیداتیو، مشکلات اصلی در پره‌اکلامپسی هستند. تاکنون ژن‌های مرتبط و بیومارکرهای مختلفی، گزارش شده‌اند که امید می‌رود بتوانند تشخیص پره‌اکلامپسی را بهبود بخشند. علاوه بر این، پروتئومیکس و متابولومیکس، بینش‌های جدیدی را در رابطه با فهم عوامل ایجادکننده‌ی بیماری و همچنین درمان آن فراهم آورده‌اند.نتیجه‌گیری: پره‌اکلامپسی یک بیماری پیچیده و چند عاملی است که باید از جهات گوناگون مورد ارزیابی قرار گیرد. این مقاله مروری روش‌های جدید برای تشخیص و درمان این اختلال را معرفی می‌نماید.

کلیدواژه‌ها

عنوان مقاله [English]

Preeclampsia in a Cellular and Molecular View

نویسندگان [English]

  • Tayebeh Amirian 1
  • Soheila Rahgozar 2
  • Zahra Shahshahan 3
1 MSc Student, Department of Biology, School of Science, University of Isfahan, Isfahan, Iran
2 Assistant Professor, Department of Biology, School of Science, University of Isfahan, Isfahan, Iran
3 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Preeclampsia is a multisystem disorder of pregnancy, which complicates 3-5% of pregnancies. It is a major cause of maternal and neonatal mortality worldwide. Despite decades of research, the etiology of preeclampsia has remained unknown and undetectable prior to the onset of symptoms. The current review article discusses different aspects of preeclampsia in order to delineate the pathophysiology of the disease.Methods: This study has reviewed 96 publications explaining the various characteristics of preeclampsia including etiology, genetics, proteomics and metabolomics, using EBSCO, OVID, PubMed, Elsevier and NCBI databases.Findings: Based on the published studies, endothelial dysfunction and oxidative stress are the major problems in preeclampsia. Related genes and biomarkers are reported which may improve the diagnosis of preeclampsia. Proteomics and metabolomics have provided new insights into better understanding of the etiology and management of the disease.Conclusion: Preeclampsia is a complicated and multifactorial disease which needs to be evaluated in different aspects. This review article introduces novel approaches to the diagnosis and treatment of this disorder.

کلیدواژه‌ها [English]

  • Preeclampsia
  • Diagnosis
  • Treatment

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مجله دانشکده پزشکی اصفهان
دوره 31، شماره 234 - شماره پیاپی 234
خرداد و تیر 1392
صفحه 568-580

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  • تاریخ دریافت: 27 دی 1391
  • تاریخ بازنگری: 01 اردیبهشت 1403
  • تاریخ پذیرش: 17 فروردین 1401

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