تأثیر 8 ماه تمرین مقاومتی بر سطوح GH (Growth hormone)، 3IGFBP (3Insulin-like growth factor binding protein) و 1IGF (1Insulin-like growth factor) پلاسمای دو بیمار مبتلا به سوختگی شدید

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 کارشناس ارشد، گروه فیزیولوژی ورزش، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه اصفهان، اصفهان، ‌ایران

2 دانشیار، گروه فیزیولوژی ورزش، دانشکده‌ی تربیت بدنی و علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران

3 استادیار، گروه فیزیولوژی ورزش، دانشکده‌ی تربیت بدنی و علوم تربیتی، دانشگاه اصفهان، اصفهان، ایران

4 استادیار، گروه روان‌شناسی کودکان با نیازهای خاص، دانشکده‌ی علوم تربیتی و روان‌شناسی، دانشگاه اصفهان، اصفهان، ایران

چکیده

مقدمه: افراد مبتلا به جراحت‌های حرارتی، افزایش کاتابولیسم پروتئین، تأخیر بهبود زخم، پاسخ ایمنی ضعیف و شیوع عفونت دارند. هدف از پژوهش حاضر بررسی اثر 8 ماه تمرین مقاومتی بر سطوح GH (Growth hormone)، 3IGFBP (3Insulin-like growth factor binding protein) و 1IGF (1Insulin-like growth factor) پلاسمای افراد مبتلا به سوختگی شدید بود.روش‌ها: روش پژوهشی از نوع مورد منفرد با طرح خط پایه‌ی چندگانه‌ی شرکت کنندگان بود. آزمودنی‌های این پژوهش دو زن با سوختگی شدید (درجه‌ی 3) در دامنه‌ی سنی 30-20 سال در بیمارستان سوانح سوختگی مرکزی شهر بودند، که پس از تعیین موقعیت خط پایه، به صورت پلکانی وارد طرح پژوهشی شدند. بیماران طی 8 ماه مداخله‌ی انفرادی، تمرین‌های مقاومتی انجام دادند و یک ماه پس از پایان مداخله، به مدت 2 ماه پی در پی تحت آزمون پیگیری قرار گرفتند. ابزار سنجش پژوهش حاضر نمونه‌گیری خونی، به منظور اندازه‌گیری GH، 1IGF و 3IGFBP بود. نمونه‌های خونی به صورت ناشتا و 24 ساعت پس از تمرین‌ها در پایان هر ماه گرفته شد.یافته‌ها: بر اساس شاخص‌های آمار توصیفی و تحلیل دیداری، تمرین‌های مقاومتی در هر دو آزمودنی موجب تغییر در سطوح 1IGF، GH و 3IGFBP شد. PND (Percentage of non-overlapping data) در GH 75 درصد برای آزمودنی اول و 5/87 درصد برای آزمودنی دوم و PND در 1IGF و 3IGFBP 100 درصد برای هر دو آزمودنی به دست آمد.نتیجه‌گیری: به نظر می‌رسد تمرین مقاومتی طولانی مدت بتواند باعث افزایش عوامل رشدی در افراد مبتلا به سوختگی شدید شود و یک محرک قوی برای سنتز پروتئین در این افراد باشد، یا از اثرات کاتابولیکی به وجود آمده پس از سوختگی و یا روند معکوس و کاهش بیش از حد این عوامل رشدی، پس از سوختگی جلوگیری کند و در نتیجه، باعث تسریع در بهبود جراحت‌ها شود.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Eight Months of Resistive Training on Growth hormone, Insulin-Like Growth Factor1 and Insulin-like Growth Factor Binding Protein3 Plasma Levels in Patients with Severe Burns

نویسندگان [English]

  • Nasim Behzadnezhad 1
  • Sayyed Mohammad Marandi 2
  • Fahimeh Esfarjani 3
  • Ahmad Abedi 4
  • Fereshteh Bardia 1
1 Department of Exercise Physiology, School of Physical Education and Sport Science, University of Isfahan, Isfahan, Iran
2 Associate Professor, Department of Exercise Physiology, School of Physical Education and Sport Science, University of Isfahan, Isfahan, Iran
3 Assistant Professor, Department of Exercise Physiology, School of Physical Education and Sport Science, University of Isfahan, Isfahan, Iran
4 Assistant Professor, Department of Psychology of Exceptional Children, School of Education Sciences and Psychology, University of Isfahan, Isfahan, Iran
چکیده [English]

Background: The aim of this study was to investigate the effect of eight months of resistive training on growth hormone (GH), insulin-like growth factor1 (IGF1), and insulin-like growth factor binding protein3 (IGFBP3) plasma levels in patients with severe burns.Methods: The research method used in this study was of the individual-case type with multiple base lines for the participants. The examinees of this study included two women with severe burns (third degree) in the age range of 20 to 30 years confined in the Central Accidents and Burns Hospital, Isfahan, Iran. After determining the base-line position, the participants were entered into the project in a ladder step-by-step format. During the 8 months of individual intervention, they did the resistive training and one month after the finishing of the intervention period, they were put under follow-up examinations for 2 months. The measuring tool for this study was the blood tests taken for measuring GH, IGF1, and IGFBP3 plasma levels, which were taken at the fasting morning time and 24 hours after the exercises at the end of each month.Findings: Based on the visual analysis and descriptive statistical indexes, the resistive training in both examinees had caused a significant change in the GH, IGF1 and IGFBP3 plasma levels; as the percentage of non-overlapping data (PND) was 75% for the first and 87.5% for the second examinee in GH level, and 100% for both examinees in IGF1 and IGFBBP3 levels.Conclusion: It seems that long-term resistive training can cause elevation of the plasma level of some growth factors in patients with severe burns or it can prevent the reverse process and intense decline in these factors after the burn takes place. In addition, it would make these patients become free of the need for frequent surgeries and using different equipments.

کلیدواژه‌ها [English]

  • Burn
  • Growth hormone (GH)
  • Insulin-like growth factor1 (IGF1)
  • Insulin-like growth factor binding protein3 (IGFBP3)
  • Resistive exercise
  • Single subject research

مراجع

  1. Wiliams C. Assessment and management of pediatric burn injuries. Nurs Stand 2011; 25(25): 60-8.
  2. Balasubramaniam A, Wood S, Joshi R, Su C, Friend LA, Sheriff S, et al. Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: synthesis of ghrelin. Peptides 2006; 27(7): 1624-31.
  3. Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE, Norbury WB, et al. Pathophysiologic response to severe burn injury. Ann Surg 2008; 248(3): 387-401.
  4. Demling RH. Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury. Burns 1999; 25(3): 215-21.
  5. Mlcak RP, Suman OE, Murphy K, Herndon DN. Effects of growth hormone on anthropometric measurements and cardiac function in children with thermal injury. Burns 2005; 31(1): 60-6.
  6. Ormsbee M, Clapper JA, Clapper J, Vukovich MD. Moderate changes in energy balance combined with exercise do not alter insulin-like growth factor I or insulin-like growth factor binding protein 3. Nutrition Research 2006; 26(9): 467-73.
  7. Newsome TW, Mason AD, Pruitt BA. Weight loss following thermal injury. Ann Surg 1973; 178(2): 215-7.
  8. Edelman LS, McNaught T, Chan GM, Morris SE. Sustained bone mineral density changes after burn injury. J Surg Res 2003; 114(2): 172-8.
  9. Suman OE, Herndon DN. Effects of cessation of a structured and supervised exercise conditioning program on lean mass and muscle strength in severely burned children. Arch Phys Med Rehabil 2007; 88(12 Suppl 2): S24-S29.
  10. Yasuhara S, Kaneki M, Sugita H, Sugita M, Asai A, Sahani N, et al. Adipocyte apoptosis after burn injury is associated with altered fat metabolism. J Burn Care Res 2006; 27(3): 367-76.
  11. Aili Low JF, Barrow RE, Mittendorfer B, Jeschke MG, Chinkes DL, Herndon DN. The effect of short-term growth hormone treatment on growth and energy expenditure in burned children. Burns 2001; 27(5): 447-52.
  12. Low JF, Herndon DN, Barrow RE. Effect of growth hormone on growth delay in burned children: a 3-year follow-up study. Lancet 1999; 354(9192): 1789.
  13. Krogh J, Nordentoft M, Mohammad-Nezhad M, Westrin A. Growth hormone, prolactin and cortisol response to exercise in patients with depression. J Affect Disord 2010; 125(1-3):
  14. -97.
  15. Lang Ch, Nystrom GJ, Frost RA. Burn-induced changes in IGF-I and IGF-binding proteins are partially glucocorticoid dependent. Am J Physiol 2002; 51(1): 207-15.
  16. Tarpenning KM, Wiswell RA, Hawkins SA, Marcell TJ. Influence of weight training exercise and modification of hormonal response on skeletal muscle growth. J Sci Med Sport 2001; 4(4): 431-46.
  17. Velloso CP. Regulation of muscle mass by growth hormone and IGF-I. Br J Pharmacol 2008; 154(3): 557-68.
  18. De Palo EF, Gatti R, Lancerin F, Cappellin E, Spinella P. Correlations of growth hormone (GH) and insulin-like growth factor I (IGF-I): effects of exercise and abuse by athletes. Clin Chim Acta 2001; 305(1-2): 1-17.
  19. Aleman A, Torres-Aleman I. Circulating insulin-like growth factor I and cognitive function: neuromodulation throughout the lifespan. Prog Neurobiol 2009; 89(3): 256-65.
  20. Suetta Ch, Clemmensen C, Andersen JL, Magnusson SP, Schjerling P, Kjaer M. Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients. Growth Horm IGF Res 2010; 20(2): 134-40.
  21. Wahl P, Zinner C, Achtzehn S, Bloch W, Mester J. Effect of high- and low-intensity exercise and metabolic acidosis on levels of GH, IGF-I, IGFBP-3 and cortisol. Growth Horm IGF Res 2010; 20(5): 380-5.
  22. Lal SO, Wolf SE, Herndon DN. Growth hormone, burns and tissue healing. Growth Horm IGF Res 2000; 1(Suppl B): S39-S43.
  23. Fang CH, Li BG, Wang JJ, Fischer JE, Hasselgren PO. Treatment of burned rats with insulin-like growth factor I inhibits the catabolic response in skeletal muscle. Am J Physiol 1998; 275(4 Pt 2): R1091-R1098.
  24. Fukushima R, Saito H, Inoue T, Fukatsu K, Inaba T, Han I, et al. Prophylactic treatment with growth hormone and insulin-like growth factor I improve systemic bacterial clearance and survival in a murine model of burn-induced gut-derived sepsis. Burns 1999; 25(5): 425-30.
  25. Kraemer WJ, Ratamess NA. Hormonal responses and adaptations to resistance exercise and training. Sports Med 2005; 35(4): 339-61.
  26. Stokes K. Growth hormone responses to sub-maximal and sprint exercise. Growth Horm IGF Res 2003; 13(5): 225-38.
  27. Gharakhanlou R, Saremi A, Omidfar K, Sharghi S, Gheraati MR. The effect of resistance training on myostatin, GASP1, IGF1 and IGFBP3 serum Levels in young man. Journal of Movement Science and Sports 2009; 7(13): 67-80. [In Persian].
  28. Ben OO, Elloumi M, Zouhal H, Makni E, Denguezli M, Amri M, et al. Effect of individualized exercise training combined with diet restriction on inflammatory markers and IGF-1/IGFBP-3 in obese children. Ann Nutr Metab 2010; 56(4): 260-6.
  29. Sadeghi-Boroujerdi S, Rahimi R. GH and IGF-1 hormone response to the fierce resistance of two different volume resting between sets. Olympic 2009; 17(1): 57-68. [In Persian].
  30. Rajabi H, Razmjo S, Jannati M, Zarifi I. Response relationship of insulin-like growth factor and creatine kinase after a six-week session, and resistance training pyramid and reverse pyramid of athletic girls. Olympic 2010; 18(2): 29-42. [In Persian].
  31. Marandi M, Mohebi H, Gharakhanlo R, Naderi Gh. Reactions IGFBPS, IGF1, GH and testosterone in a strenuous physical activity sessions. Olympic 2004; 12(4): 7-15. [In Persian].
  32. Alloju SM, Herndon DN, McEntire SJ, Suman OE. Assessment of muscle function in severely burned children. Burns 2008; 34(4): 452-9.
  33. Melchert-McKearnan K, Deitz J, Engel JM, White O. Children with burn injuries: purposeful activity versus rote exercise. Am J Occup Ther 2000; 54(4): 381-90.
  34. Farahani H, Abedi A, Aghamohammadi S, Kazemi S. Single subject researches methodology in behavioral sciences and medicine (approach-applied). Tehran, Iran: Danjeh Publication; 2010. [In Persian].
مجله دانشکده پزشکی اصفهان
دوره 32، شماره 279 - شماره پیاپی 279
فروردین و اردیبهشت 1393
صفحه 388-407

فایل ها

سابقه مقاله

  • تاریخ دریافت: 15 مرداد 1392
  • تاریخ بازنگری: 30 فروردین 1403
  • تاریخ پذیرش: 17 فروردین 1401

هم رسانی

ارجاع به این مقاله

آمار