مقایسه‌ی شیوع استئوپروز در زنان یائسه‌ی مبتلا و غیر مبتلا به دیابت شیرین نوع 2

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دستیار، گروه داخلی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 استادیار، گروه روماتولوژی، دانشکده‌ی پزشکی، دانشگاه بقیه‌اله (عج)، تهران، ایران

3 دانشیار، گروه روماتولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

4 دانشیار، گروه پزشکی اجتماعی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

5 استادیار، گروه روماتولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: مروری بر متون موجود حاکی از وجود یافته‌های مختلف و گاه متناقض در مورد ارتباط بین استئوپورز و دیابت شیرین در زنان یائسه می‌باشد. این مطالعه با هدف ارزیابی ارتباط بین استئوپورز و دیابت نوع 2 در زنان پس از یائسگی اجرا گردید.روش‌ها: مطالعه‌ی حاضر یک مطالعه‌ی مقطعی بود که 200 زن یائسه‌ی مبتلا به دیابت با سن بالای 60 سال، با 400 زن یائسه‌ی غیر مبتلا به دیابت از نظر دانسیته‌ی استخوانی بر اساس T score در نواحی ستون فقرات کمری از (4L-2L) و سر استخوان فمور به روش دگزا (DXA یا Dual-energy X-ray absorptiometry) انجام شد و داده‌ها با هم مقایسه شدند. برای آنالیز داده‌ها از نرم‌افزار SPSS نسخه‌ی 18 و آزمون‌های 2χ، Fisher's exact و t استفاده گردید. در این مطالعه، 050/0 > P به عنوان سطح معنی‌داری در نظر گرفته شد.یافته‌ها: متوسط سنی بیماران مبتلا به دیابت 78/5 ± 91/66 سال در برابر 80/4 ± 23/65 زنان سالم و شاخص توده‌ی بدنی به ترتیب 42/4 ± 65/31 در برابر 06/4 ± 94/28 بود. T score توتال ستون فقرات کمری 27/1 ± 16/2- در برابر 08/1 ± 10/2-، (060/0 = P) و T score گردن فمور 96/0 ± 09/1- در برابر 00/1 ± 72/0-، بود (001/0 > P). میزان از دست رفتن توده‌ی استخوانی به صورت معنی‌داری در زنان مبتلا به دیابت یائسه بیشتر بود. همچنین از دست رفتن توده‌ی استخوانی در بیمارانی که 7 ≤ C1HbA (Glycated hemoglobin) داشتند، بیشتر از افراد با 7 > C1HbA بود (006/0 = P).نتیجه‌گیری: نتایج این مطالعه بیماری دیابت نوع 2 را به عنوان یکی از عوامل خطر شیوع از دست رفتن استخوان در زنان یائسه معرفی نمود. از این رو، کنترل این عامل خطر می‌تواند به عنوان یک مداخله‌ی مهم در پیشگیری از ابتلا به استئوپورز مطرح باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Comparison of the Prevalence of Osteopenia and Osteoporosis in Postmenopausal Women with and without Type 2 Diabetes Mellitus

نویسندگان [English]

  • Morteza Aghajanpoor 1
  • Amirhossein Salari 2
  • Mansoor Karimifar 3
  • Ahmadreza Zamani 4
  • Mansour Salesi 3
  • Peyman Mottaghi 5
1 Resident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Department of Rheumatology, School of Medicine, Baghiyatallah University of Medical Sciences, Tehran, Iran
3 Associate Professor, Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Associate Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5 Associate Professor, Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Osteoporosis and diabetes mellitus are major and growing public health problems, particularly among postmenopausal women. This study was conducted to evaluate the relationship between osteoporosis and type 2 diabetes mellitus (DM) in postmenopausal women.Methods: In this cross sectional study, we compared 200 postmenopausal women with type 2 diabetes mellitus and 400 without it, over the age of 60 years. Age, body mass index (BMI), and the T-score of the lumbar vertebra, neck of femur measured via Dual Energy X-ray Absorptiometry (DEXA) were recorded and compared between the two groups. Hemoglobin A1C (HbA1C) was also measured in patients with type 2 diabetes mellitus and its correlation with osteoporosis was studied. Chi-square, Fisher’s exact and independent t tests were used for analyzing the data. In this study, P-value less than 0.05 was considered as significant.Findings: The mean ages were 65.23 ± 4.80 vs. 66.91 ± 5.78 years and BMI were 28.94 ± 4.06 vs. 31.65 ± 4.42 kg/m2 in non-diabetic and diabetic groups, respectively. Lumber T-scores was -2.10 ± 1.08 vs. -2.16 ± 1.27 (P = 0.60), femoral neck T-score was -0.72 ± 1.00 vs. -1.09 ± 0.96 (P < 0.01), in non-diabetic and diabetic groups, respectively. The prevalence of osteopenia and osteoporosis was statistically higher among diabetic group compared to non-diabetics. In diabetic group, osteoporosis was more common in those with HbA1C ≥ 7 compared to those with HbA1C < 7 (P = 0.006).Conclusion: The results of this study showed that bone loss is more common in postmenopausal women ith type 2 diabetes mellitus compared to the postmenopausal women without it. We can control this risk factor, as an important intervention, in the prevention of osteoporosis.

کلیدواژه‌ها [English]

  • Postmenopausal women
  • Type 2 Diabetes Mellitus
  • Osteopenia
  • Osteoporosis

مراجع

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مجله دانشکده پزشکی اصفهان
دوره 32، شماره 289 - شماره پیاپی 289
مرداد و شهریور 1393
صفحه 889-900

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سابقه مقاله

  • تاریخ دریافت: 02 اردیبهشت 1391
  • تاریخ بازنگری: 07 اردیبهشت 1403
  • تاریخ پذیرش: 17 فروردین 1401

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