بررسی نتایج حاصل از درمان توسط تکنیک‌های کمک باروری در بیمارستان شهید بهشتی اصفهان

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دانشیار، گروه علوم تشریحی، دانشکده‌ی پزشکی و آزمایشگاه نازایی، بیمارستان شهید بهشتی اصفهان، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 متخصص زنان و زایمان، بخش نازایی، بیمارستان شهید بهشتی اصفهان، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 آزمایشگاه نازایی، بیمارستان شهید بهشتی اصفهان، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

4 بخش نازایی، بیمارستان شهید بهشتی اصفهان، اصفهان، ایران

5 استادیار، گروه علوم تشریحی، دانشکده‌ی پزشکی و آزمایشگاه نازایی بیمارستان شهید بهشتی اصفهان، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: امروزه استفاده از تکنیک‌های کمک باروری، مشکل بسیاری از افراد نابارور را برطرف نموده است. تکرار سیکل‌های درمانی، صرف وقت و هزینه‌ی به نسبت زیاد و مشکلات احتمالی ناشی از بیهوشی‌های مکرر، محققین را به سمت یافتن راه‌هایی برای پیش‌بینی میزان موفقیت هر یک از تکنیک‌ها هدایت نموده است. این تحقیق، با هدف بررسی میزان موفقیت روش‌های کمک باروری انجام گرفت.روش‌ها: مطالعه‌ی حاضر، گذشته نگر بود و جمعیت مورد مطالعه، 71 زوجی بودند که طی شش ماهه‌ی اول سال 1392 جهت انجام تکنیک‌های کمک باروری به مرکز درمان ناباروری شهید بهشتی شهر اصفهان مراجعه کرده بودند. معیار اصلی در حصول نتایج، بارداری بالینی دو هفته پس از قرار دادن جنین در رحم مادر بود. اطلاعات مورد نیاز مانند سن و نتایج آزمایش‌های مایع منی و نیز نتیجه‌ی حاصل از انجام تکنیک‌های کمک باروری، از پرونده‌ی این بیماران استخراج شد.یافته‌ها: از کل زوج‌های تحت بررسی، 42 مورد تحت درمان به روش تلقیح داخل رحمی اسپرم (IUI یا Intrauterine insemination) و 29 مورد تحت درمان به روش لقاح آزمایشگاهی (IVF/ICSI یا In vitro fertilization/Intracytoplasmic sperm injection) قرار گرفتند. از 42 دوره IUI، 10 دوره‌ی موفق (8/23 درصد) و از 29 دوره IVF/ICSI نیز 7 دوره‌ی موفق (1/24 درصد) دیده شد. میانگین سنی زنان و مردان و مدت زمان ناباروری در دو گروه موفق و ناموفق در مورد روش IUI اختلاف آماری معنی‌داری نداشت. در حالی که این میانگین در مورد روش IVF/ICSI معنی‌دار بود. میان پارامتر‌های اسپرمی نیز بین دو گروه موفق و ناموفق در گروه درمانی IUI ارتباط آماری معنی‌داری یافت نشد، اما در مورد گروه درمانی IVF/ICSI درصد اسپرم‌های سریع به صورت معنی‌داری در دو گروه موفق و ناموفق متفاوت بود.نتیجه‌گیری: آنالیز مرسوم منی و سن زن و شوهر نمی‌توانند پیش‌بینی کننده‌ی نتایج استفاده از روش IUI باشند، اما میزان موفقیت روش IVF/ICSI در موارد سن پایین‌تر زوجین، همچنین مدت زمان ناباروری کمتر و پارامترهای اسپرمی بهتر، افزایش می‌یابد. 

کلیدواژه‌ها


عنوان مقاله [English]

Evaluation of the Success Rate of Assisted Reproductive Techniques (ART) in Shahid Beheshti Infertility Center, Isfahan, Iran

نویسندگان [English]

  • Roshanak Abutorabi 1
  • Vida Razavi 2
  • Shekufeh Baghazadeh 3
  • Laleh Sharegh 4
  • Fatemeh Sadat Mostafavi 5
1 Associate Professor, Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences AND Infertility Laboratory, Shahid Beheshti Hospital, Isfahan, Iran
2 Gynecologist, Department of Infertility, Shahid Beheshti Hospital, Isfahan, Iran
3 Infertility Laboratory, Shahid Beheshti Hospital, Isfahan, Iran
4 Department of Infertility, Shahid Beheshti Hospital, Isfahan, Iran
5 Assistant Professor, Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences AND Infertility Laboratory, Shahid Beheshti Hospital, Isfahan, Iran
چکیده [English]

Background: Today, usage of assisted reproductive techniques (ART) has been resolved the problem of many infertile couples. Repeated treatment cycles, long time and high cost, problems due to repeated anesthesia, has been directed the researchers to find ways to predict the success rate of each method. This study aimed to evaluate the success of assisted reproductive techniques in Isfahan Shahid Beheshti infertility center, Iran.Methods: In this retrospective study, 71 couples referred to this center for assisted reproductive techniques during the first six months of 2013 were enrolled. The main criterion for a positive result was clinical pregnancy two weeks after embryo transfer. Required information such as age, semen analysis and outcome of assisted reproductive techniques, were obtained from patients' medical records.Findings: Of all couples, 42 cases were treated with intrauterine insemination (IUI) and 29 cases were treated with in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). 23.8% of IUI cycles and 24.1% of IVF/ICSI cycles were successful. The mean age and duration of infertility in both successful and unsuccessful IUI groups were not statistically significant; while these diferences in the cases of IVF/ICSI were significant. In addition, there were no significant differences between the sperm parameters in successful and unsuccessful IUI treated groups; but in IVF/ICSI treated group, we found significant differences in the percent of fast motile sperms between successful and unsuccessful groups.Conclusion: Conventional analysis of semen and couple’s age cannot predict the outcome of IUI; but the success rate of IVF/ICSI is related to the age of couples, as well as shorter duration of infertility and better semen parameters.

کلیدواژه‌ها [English]

  • Infertility
  • Intrauterine insemination
  • In-vitro fertilization
  • Intracytoplasmic sperm injection
  • Sperm parameters
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