مجله دانشکده پزشکی اصفهان

مجله دانشکده پزشکی اصفهان

اثرات حفاظت کلیوی متفورمین

نوع مقاله : مقاله کوتاه

نویسندگان
محمود رفیعیان کوپایی 1
فاطمه قائد امینی 2
حمید نصری 3
1 استاد، مرکز تحقیقات گیاهان دارویی، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران
2 پزشک عمومی، مرکز تحقیقات گیاهان دارویی، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران
3 استاد، گروه نفرولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
چکیده
متفورمین به عنوان یک دارو از دسته‌ی بی‌گوانیدها حدود 50 سال پیش وارد بازار دارویی شد و هم اکنون به عنوان یک داروی خط اول در درمان دیابت نوع 2، به خصوص در افراد با وزن بالا مطرح است. در سال‌های اخیر، برای این دارو کاربردهای جدیدی نیز مطرح شده است. از جمله این که به این دارو، به عنوان محافظ کلیه توجه زیادی می‌شود. مطالعات اخیر، مشخص کرده‌اند که متفورمین خواص آنتی‌اکسیدانی خوبی دارد. کاهش آپوپتوز ناشی از اکسیداتیو استرس در سلول‌های اندوتلیال و مهار اختلالات عروقی نیز با مصرف متفورمین گزارش شده است. 
کلیدواژه‌ها
متفورمین
حفاظت کلیوی
استرس اکسیداتیو
آنتی اکسیدان

عنوان مقاله English

Metformin and Renal Protection

نویسندگان English

Hamid Nasri 3
Fatemeh Ghaed-Amini 2
1 Professor, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 General Practitioner, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Professor, Department of Nephrology, School Of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده English

Metformin as a biguanid drug entered to the market 50 years ago, and now is generally recommended as the first-line treatment of type 2 diabetes mellitus, especially in overweight patients. However, in recent years ,new indications for its use have found. Recently, much attention has been directed toward the possible renal protective efficiency of metformin. Recent studies have proven that metformin, possesses antioxidant efficacy as well. Reduction of apoptosis, induced by oxidative stress in endothelial cells and prevention of vascular dysfunction is found with metformin treatment, too. 

کلیدواژه‌ها English

Metformin
Renal protection
Oxidative Stress
Antioxidant
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مجله دانشکده پزشکی اصفهان
دوره 32، شماره 307 - شماره پیاپی 307
آذر و دی 1393
صفحه 1832-1837

  • تاریخ دریافت 21 تیر 1392
  • تاریخ پذیرش 17 فروردین 1401