1
Student of Medicine, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
2
Assistant Professor, Department of Physiology and Pharmacology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
3
Assistant Professor, Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
Abstract
Background: A known problem of chronic administration of opioid is tolerance to its analgesic effect. Co-administration of a non-opioid analgesic may help reducing the opiate dose and consequently tolerance and dependency. It is reported that repeated use of methylphenidate, one of amphetamines, increased the expression of µ opioid receptor and had antinociception. Therefore, this study aimed to evaluate the effect of methylphenidate on methadone-induced analgesia.Methods: Nine groups of 8 male rats weighting 270 ± 20 g were randomly selected; control group received 1 ml/kg oral normal saline, metylphenidate groups received 5, 10 and 15 mg/kg oral metylphenidate, methadone groups received 5, 10, 20 mg/kg oral methadone, and combined groups received 5 mg/kg methadone +5 or 15 mg/kg methylphenidate orally. Pain was measured using plantar test apparatus.Findings: Only, 15 mg/kg methylphenidate produced significant analgesic effect. In addition, co-administration of non-effective doses of methylphenidate and 5 mg/ kg methadone significantly increased the analgesic effects of methadone at 60 minutes after gavage.Conclusion: We found that methylphenidate potentiate the analgesic effects of methadone in rats.
Hassanzadeh K, Izadpanah E. Neuroprotection and pain management. In: Racz GB, Noe CE, editors. Pain management-current issues and opinions. Rijeka, Croatia: In Tech; 2011. p. 81-100.
Finnerup NB, Otto M, McQuay HJ, Jensen TS, Sindrup SH. Algorithm for neuropathic pain treatment: an evidence based proposal. Pain 2005; 118(3): 289-305.
Nestler EJ, Hyman SE, Malenka R. Molecular Neuropharmacolog. 4th ed. New York, NY: Mcgraw-Hill; 2001. p. 355-80.
Cyr MC, Morgan MM. Early methylphenidate exposure enhances morphine antinociception and tolerance in adult rats. Neuropharmacology 2009; 57(7-8): 673-7.
Halladay LR, Iniguez SD, Furqan F, Previte MC, Chisum AM, Crawford CA. Methylphenidate potentiates morphine-induced antinociception, hyperthermia, and locomotor activity in young adult rats. Pharmacol Biochem Behav 2009; 92(1): 190-6.
Basic and Clinical Pharmacology. 11th ed. New York, NY: McGraw-Hill; 2009. p. 141-2.
Zhu J, Spencer TJ, Liu-Chen LY, Biederman J, Bhide PG. Methylphenidate and mu opioid receptor interactions: a pharmacological target for prevention of stimulant abuse. Neuropharmacology 2011; 61(1-2): 283-92.
Yaghoutpoor E, Kiasalari Z, Khalili M, Vahidi S. Combination effect of methadone and haloperidol on morphine withdrawal-induced anxiety in male mice. J Babol Univ Med Sci 2014; 16(3): 41-8. [In Persian].
Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32(1): 77-88.
Amini Y, Moloudi R, Izadpanah E, Hassanzadeh K. N-acetylcysteine provides analgesic effect in rats. J Isfahan Med Sch 2013; 31(257): 1682-9. [In Persian].
Bruera E, Chadwick S, Brenneis C, Hanson J, MacDonald RN. Methylphenidate associated with narcotics for the treatment of cancer pain. Cancer Treat Rep 1987; 71(1): 67-70.
Howard P, Shuster J, Twycross R, Mihalyo M, Wilcock A. Psychostimulants. J Pain Symptom Manage 2010; 40(5): 789-95.
Weiss B, Laties VG. Enhancement of human performance by caffeine and the amphetamines. Pharmacol Rev 1962; 14: 1-36.
Forrest WH, Jr., Brown BW, Jr., Brown CR, Defalque R, Gold M, Gordon HE, et al. Dextroamphetamine with morphine for the treatment of postoperative pain. N Engl J Med 1977; 296(13): 712-5.
Arner S, Meyerson BA. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 1988; 33(1): 11-23.
Dalal S, Melzack R. Potentiation of opioid analgesia by psychostimulant drugs: a review. J Pain Symptom Manage 1998; 16(4): 245-53.
Zanjani,B. , Moloudi,M. R. , Izadpanah,E. and Hassanzadeh,K. (2015). Effect of Methylphenidate on Methadone-Induced Analagesia in Rat. Journal of Isfahan Medical School, 33(327), 316-325.
MLA
Zanjani,B. , , Moloudi,M. R. , , Izadpanah,E. , and Hassanzadeh,K. . "Effect of Methylphenidate on Methadone-Induced Analagesia in Rat", Journal of Isfahan Medical School, 33, 327, 2015, 316-325.
HARVARD
Zanjani B., Moloudi M. R., Izadpanah E., Hassanzadeh K. (2015). 'Effect of Methylphenidate on Methadone-Induced Analagesia in Rat', Journal of Isfahan Medical School, 33(327), pp. 316-325.
CHICAGO
B. Zanjani, M. R. Moloudi, E. Izadpanah and K. Hassanzadeh, "Effect of Methylphenidate on Methadone-Induced Analagesia in Rat," Journal of Isfahan Medical School, 33 327 (2015): 316-325,
VANCOUVER
Zanjani B., Moloudi M. R., Izadpanah E., Hassanzadeh K. Effect of Methylphenidate on Methadone-Induced Analagesia in Rat. JIMS, 2015; 33(327): 316-325.
