نوع مقاله : مقاله های پژوهشی
1 استادیار، گروه داخلی مغز و اعصاب، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
2 استادیار، مرکز تحقیقات غدد و متابولیسم، دانشگاه علوم پزشکی اصفهان و گروه فارماکولوژی، دانشکدهی علوم پزشکی، دانشگاه آزاد اسلامی، واحد نجف آباد، اصفهان، ایران
3 استاد، گروه داخلی مغز و اعصاب، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
عنوان مقاله [English]
Background: Recent studies have focused on a positive correlation between Helicobacter pylori (H. pylori) infection and occurrence of migraine headache. This study aimed to determine the role of H. pylori infection in the two common types of migraine headache including with (MA) and without aura (MO).Methods: In a case-control study, 84 patients (with MA or MO migraine headache) and 49 healthy individuals were enrolled. The enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of immunoglobulin G (IgG) and M (IgM) against H. Pylori in patients and controls.Findings: The mean age was 35.8 ± 11.1 and 33.4 ± 18.9 years in patient and control groups, respectively. The mean level of IgM antibody was significantly more in patients (26.3 ± 23.1 U/ml) compared to control group (17.5 ± 11.2 U/ml) (P = 0.004). It was not any significant difference between the levels of IgM and IgG antibodies in patients with MA or MO migraine headache. In addition, the mean HIT6 score was significantly more in patients with MA (65.5 ± 4.7) compared to those with MO (54.9 ± 5.3) migraine headache (P < 0.001). The only significant correlation was found between the IgG antibody level and the HIT6 score in patients with MA (r = 0.407; P = 0.011) and MO (r = 0.499; P = 0.002) migraine headache. There was significant relationship between the normal and high levels of IgG antibody and the severity of headache (P = 0.002) in all the patients. The risk of migraine occurrence in patients was not significantly associated with the levels of IgG and IgM antibodies.Conclusion: Further investigation should be designed to gain better conclusion about the role of H. Pylori treatment and eradication in the course of migraine headaches.