تأثیر تمرین هوازی بر تمایل به مصرف مورفین در موش صحرایی نر

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 کارشناسی ارشد، گروه فیزیولوژی ورزش، دانشکده‌ی علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران

2 استاد، گروه فیزیولوژی ورزش، دانشکده‌ی علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران

3 استاد، گروه فیزیولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

چکیدهمقدمه: تحقیقات متعددی بیان می‌دارد که عوامل گوناگونی نظیر ورزش، بر ایجاد و استمرار اعتیاد تأثیر به‌سزایی دارند. کاربرد ورزش با نوع و مدت زمان‌های مختلف، اثرات متفاوتی را نشان داده است. از این رو، در مطالعه‌ی حاضر تأثیر 4 هفته تمرین هوازی بر تمایل به مصرف مورفین در موش صحرایی ارزیابی شد.روش‌ها: این مطالعه بر روی 24 رت نر نژاد ویستار انجام شدکه به 4 گروه سالین، مورفین، سالین- ورزش و مورفین- ورزش تقسیم شدند. ابتدا موش‌ها آموزش داده شدند تا با فشار دادن پدال دستگاه خود تزریقی، غذا دریافت کنند. پس از بیهوشی، ورید ژوگولار کانوله شد. رت‌ها بعد از بهبودی، هر روز دو ساعت به مدت 11 روز داخل دستگاه قرار داده شدند که 6 روز اول با محدودیت غذا و 5 روز آخر بدون محدودیت غذا بود. گروه‌های ورزش قبل از جراحی به مدت 4 هفته روی تردمیل دویدند. در پایان، تعداد پدال‌های فشار داده شده ثبت و ارزیابی شد. سپس، در روز یازدهم علایم ترک اعتیاد اندازه‌گیری شد.یافته‌ها: تفاوت معنی‌داری در علایم ترک و تعداد پدال‌های فعال در گروه‌های مختلف وجود داشت (050/0 > P)، اما در تعداد پدال‌های غیر فعال بین گروه‌ها، اختلاف معنی‌دار مشاهده نشد.نتیجه‌گیری: تمرین هوازی می‌تواند از میزان تمایل به مصرف مورفین جلوگیری کند و علایم ترک را کاهش دهد. با توجه به این که سیستم دوپامین در اعتیاد نقش مهمی دارد، احتمال می‌رود ورزش از این طریق اثرات خود را اعمال کرده باشد.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Aerobic Exercise on Tendency to Consumption of Morphine in Male Rat

نویسندگان [English]

  • Somayeh Ahmadi 1
  • Mehdi Kargarfard 2
  • Hojatallah Alaei 3
1 Department of Sport Physiology, School of Sport Sciences, University of Isfahan, Isfahan, Iran
2 Professor, Department of Sport Physiology, School of Sport Sciences, University of Isfahan, Isfahan, Iran
3 Professer, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

AbstractBackground: Several investigations have suggested that many factors affect the creation and perpetuation of morphine addiction such as exercise. Applying exercise with different lengths and types showed different effects on this addiction. This study aimed to assess the influence of four weeks of aerobic exercise on the desire to consume morphine in male rats.Methods: This study was done on 24 male wistar rats divided into 4 equal groups of saline, morphine, saline-exercise and morphine-exercise. At first, the rats were trained to receive small pallets with pressing active lever in self-administration apparatus. Then, all animals were anaesthetized and the jugular vein was cannulated. After recovery, the animals were placed into the self-administration apparatus 2 hours a day for 11 days. The first 6-days, animals were food-restricted and the later 5 days, were without food restriction. The exercise groups ran on the treadmill for 4 weeks before surgery. Finally, the numbers of lever pressing were recorded and evaluated. After 11 days, withdrawal symptoms were measured.Findings: The number of active lever pressing, and withdrawal symptoms were significantly difference among the groups; but there was no significant difference in number of passive lever pressing between the groups (P < 0.05).Conclusion: The results of this study showed that probably, aerobic exercise can prevent tendency to consumption of morphine and reduce withdrawal symptoms in rats. It is possible that exercise exerts the effect on morphine addiction via the dopamine system.

کلیدواژه‌ها [English]

  • Aerobic Exercise
  • Tendency to morphine
  • Rat
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