نقش کورکومین در پیش‌گیری و درمان سرطان روده‌ی بزرگ و مکانیسم‌های آن

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی دکتری، گروه فیزیولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

2 استادیار، گروه بیوشیمی، دانشکده‌ی پزشکی و مرکز تحقیقات سندرم متابولیک، دانشگاه علوم پزشکی مشهد، مشهد، ایران

3 استادیار، گروه فن‌آوری‌های نوین، دانشکده‌ی پزشکی و مرکز تحقیقات سرطان، دانشگاه علوم پزشکی مشهد، مشهد، ایران

4 استاد، گروه فیزیولوژی، دانشکده‌ی پزشکی و مرکز تحقیقات التهاب نوروژنیک، دانشگاه علوم پزشکی مشهد، مشهد، ایران

چکیده

سرطان روده‌ی بزرگ، چهارمین سرطان شایع و سومین عامل مرگ ناشی از سرطان در دنیا می‌باشد. شیمی‌درمانی به همراه جراحی، از روش‌های رایج درمان این بیماری است. داروهای سایتوتوکسیک مختلفی نظیر ۵-فلورواوراسیل، اگزالی پلاتین و لوکوورین، برای بیماران تجویز می‌گردد، اما استفاده‌ی هم‌زمان از چند داروی سایتوتوکسیک، عوارض بسیار زیادی برای بیماران به همراه دارد. از طرف دیگر، شناسایی ترکیبات جدید که منجر به افزایش پاسخ به داروها، کاهش دز مصرفی و کاهش عوارض جانبی داروهای شیمی‌درمانی گردد، بسیار حایز اهمیت خواهد بود. کورکومین، یک ماده با منشأ گیاهی است که اثرات آنتی‌اکسیدانی، ضد التهابی، ضد باکتری و ... آن در بسیاری از مطالعات مورد بررسی و تأیید قرار گرفته است. همچنین، اثرات ضد توموری این ترکیب، در مطالعات پیش‌بالینی و مراحل I و II انسانی در سرطان‌های مختلف مانند پروستات، پستان، روده‌ی بزرگ و پانکراس مورد بررسی قرار گرفته است که نتایج بعضی از این مطالعات، حاکی از اثربخشی، تحمل بهتر بیمار به درمان و افزایش کیفیت زندگی بیماران بوده است. در این مقاله‌ی مروری، به بررسی اثرات کورکومین در سرطان روده‌ی بزرگ و مکانیسم آن پرداخته شد.

کلیدواژه‌ها

عنوان مقاله [English]

Role of Curcumin in Prevention and Treatment of Colorectal Cancer: The Mechanisms

نویسندگان [English]

  • Reyhaneh Moradi-Marjaneh 1
  • Seyed Mehdi Hasanian 2
  • Amir Avan 3
  • Majid Khazaei 4
1 PhD Student, Department of Medical Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Assistant Professor, Department of Medical Biochemistry, School of Medicine AND Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3 Assistant Professor, Department of Modern Sciences and Technologies, School of Medicine AND Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4 Professor, Department of Medical Physiology, School of Medicine AND Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

Colorectal cancer is the fourth common cancer and third cause of death due to cancer in the world. Chemotherapy plus surgery are the routine methods in treatment of colorectal cancer. Cytotoxic drugs such as 5-fluorouracil, ograliplatin, and leukoverin in treating colorectal cancer have several side effects for patients. On the other hand, finding new components to improve drug responsiveness, reduce drug dosage and therefore, reduce side effects of chemotherapy are important. Curcumin is a substance of plant origin with antioxidative, anti-inflammatory, and antibacterial properties. In addition, it has antitumor effects in preclinical, and phases I and II clinical studies in various cancers such as prostate, breast, colon, and pancreas. The results of these studies indicated the efficacy, more tolerance among patients, and improving the quality of life. In this article, we reviewed the role of curcumin in colorectal cancer and the involved mechanisms.

کلیدواژه‌ها [English]

  • Curcumin
  • Cancer
  • Colorectal

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مجله دانشکده پزشکی اصفهان
دوره 35، شماره 441 - شماره پیاپی 441
مهر و آبان 1396
صفحه 969-977

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سابقه مقاله

  • تاریخ دریافت: 29 فروردین 1396
  • تاریخ بازنگری: 01 اردیبهشت 1403
  • تاریخ پذیرش: 17 فروردین 1401

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