مطالعات بالینی بر روی اثرات زعفران در بیماری‌های مختلف

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی دکتری، گروه فیزیولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

2 استادیار، گروه بیوشیمی، دانشکده‌ی پزشکی و مرکز تحقیقات سندرم متابولیک، دانشگاه علوم پزشکی مشهد، مشهد، ایران

3 استادیار، مرکز تحقیقات سرطان و گروه فن‌آوری‌های نوین، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

4 استاد، گروه فیزیولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران

چکیده

زعفران یا Crocus sativus از خانواده‌ی Iridacea است که از گذشته تا کنون در مصارف خانگی به عنوان طعم دهنده و رنگ کننده‌ی غذاها به کار می‌رود. مطالعات مختلف نشان داده است زعفران دارای ویژگی‌های فارماکولوژیک متعددی همچون اثرات ضد التهابی، آنتی‌اکسیدانی، آنتی‌پرولیفراتیو و القا کننده‌ی آپوپتوز به صورت انتخابی در سلول‌های سرطانی می‌باشد. اگر چه در مطالعات برون‌تنی و حیوانی، پژوهش‌های گسترده‌ای بر روی این گیاه انجام شده است، اما کاربرد این گیاه دارویی به صورت بالینی محدود است. با توجه به گرایش امروزه‌ی انسان‌ها به استفاده از مشتقات گیاهی به جای مشتقات شیمیایی برای درمان، باید توجه ویژه‌ای به اثرات ارزشمند زعفران معطوف گردد و پژوهش‌ها در این زمینه از سطح علوم پایه، به مطالعات بالینی سوق یابد. به منظور سهولت ارزیابی و تفکر بیشتر راجع به خواص این گیاه، مطالعه‌ی مروری حاضر، تحقیقات بالینی را که این زمبنه انجام شده‌اند، ارایه می‌نماید.

کلیدواژه‌ها

عنوان مقاله [English]

Clinical Studies on the Effect of Saffron in Different Diseases

نویسندگان [English]

  • Nastaran Rezaei 1
  • Seyed Mehdi Hasanian 2
  • Amir Avan 3
  • Majid Khazaei 4
1 PhD Student, Department of Medical Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Assistant Professor, Department of Medical Biochemistry, School of Medicine AND Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3 Assistant Professor, Cancer Research Center AND Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 Professor, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

Saffron or Crocus sativus is a member of Iridacea which traditionally has been used as flavor and color in foods. Studies indicated that saffron has different pharmacological effects such as anti-inflammatory, antioxidant, antiproliferative, and apoptosis. Although, numerous in-vitro and in-vivo studies have been done to find the different effects of this herbal drug, however, clinical usage of it is very limited. Since using herbal drugs in treatment of disease is very popular, it should be more attention on the beneficial effects of saffron which lead to clinical usage of it. In this study, to understand more about the beneficial effects of this herbal drug, we reviewed clinical studies which have been done on saffron so far.

کلیدواژه‌ها [English]

  • Saffron
  • Clinical study
  • Disease

مراجع

  1. Melnyk JP, Wang S, Marcone MF. Chemical and biological properties of the world's most expensive spice: Saffron. Food Res Int 2010; 43(8): 1981-9.
  2. Mollazadeh H, Emami SA, Hosseinzadeh H. Razi's Al-Hawi and saffron (Crocus sativus): A review. Iran J Basic Med Sci 2015; 18(12): 1153-66.
  3. Rezaei N, Avan A, Hassanian-Mehr SM, Khazaei M. Effect of crocin on inflammatory bowel diseases. J Isfahan Med Sch 2017; 34(414): 1640-7. [In Persian]. Ref Type: Generic
  4. Rojas-Gutierrez E, Munoz-Arenas G, Trevino S, Espinosa B, Chavez R, Rojas K, et al. Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration. Synapse 2017. [Epub ahead of print].
  5. Papandreou MA, Kanakis CD, Polissiou MG, Efthimiopoulos S, Cordopatis P, Margarity M, et al. Inhibitory activity on amyloid-beta aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents. J Agric Food Chem 2006; 54(23): 8762-8.
  6. Ghahghaei A, Bathaie SZ, Kheirkhah H, Bahraminejad E. The protective effect of crocin on the amyloid fibril formation of Abeta42 peptide in vitro. Cell Mol Biol Lett 2013; 18(3): 328-39.
  7. Ebrahim-Habibi MB, Amininasab M, Ebrahim-Habibi A, Sabbaghian M, Nemat-Gorgani M. Fibrillation of alpha-lactalbumin: effect of crocin and safranal, two natural small molecules from Crocus sativus. Biopolymers 2010; 93(10): 854-65.
  8. Geromichalos GD, Lamari FN, Papandreou MA, Trafalis DT, Margarity M, Papageorgiou A, et al. Saffron as a source of novel acetylcholinesterase inhibitors: Molecular docking and in vitro enzymatic studies. J Agric Food Chem 2012; 60(24): 6131-8.
  9. Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, et al. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: A 16-week, randomized and placebo-controlled trial. J Clin Pharm Ther 2010; 35(5): 581-8.
  10. Akhondzadeh S, Shafiee SM, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, et al. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease. Psychopharmacology (Berl) 2010; 207(4): 637-43.
  11. Tsolaki M, Karathanasi E, Lazarou I, Dovas K, Verykouki E, Karacostas A, et al. Efficacy and safety of Crocus sativus L. in patients with mild cognitive impairment: One year single-blind randomized, with parallel groups, clinical trial. J Alzheimers Dis 2016; 54(1): 129-33.
  12. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, Amini H, Fallah-Pour H, Jamshidi AH, et al. Crocus sativus L. in the treatment of mild to moderate depression: A double-blind, randomized and placebo-controlled trial. Phytother Res 2005; 19(2): 148-51.
  13. Moshiri E, Basti AA, Noorbala AA, Jamshidi AH, Hesameddin AS, Akhondzadeh S. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: A double-blind, randomized and placebo-controlled trial. Phytomedicine 2006; 13(9-10): 607-11.
  14. Akhondzadeh S, Mohammadi M, Khani M, Jamshidi A, Daliri A, Bastani S. Comparison of dried ethanolic extract of Croucus sativus L. and imipramine in the treatment of mild to moderate depression: A double-blind, randomised trial. J Med Plants 2003; 4(8): 55-62. [In Persian].
  15. Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi F. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern Med 2004; 4: 12.
  16. Akhondzadeh BA, Moshiri E, Noorbala AA, Jamshidi AH, Abbasi SH, Akhondzadeh S. Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: A pilot double-blind randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31(2): 439-42.
  17. Sahraian A, Jelodar S, Javid Z, Mowla A, Ahmadzadeh L. Study the effects of saffron on depression and lipid profiles: A double blind comparative study. Asian J Psychiatr 2016; 22: 174-6.
  18. Akhondzadeh Basti A, Ghoreishi S, Noorbala A, Akhondzadeh S, Rezazadeh S. Petal and stigma of Crocus sativus L. in the treatment of depression: a pilot double-blind randomized trial. Herbal Drugs 2008; 1(25): 29-36.
  19. Kell G, Rao A, Beccaria G, Clayton P, Inarejos-Garcia AM, Prodanov M. affron((R)) a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complement Ther Med 2017; 33: 58-64.
  20. Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, et al. Comparison of saffron versus fluoxetine in treatment of mild to moderate postpartum depression: A double-blind, randomized clinical trial. Pharmacopsychiatry 2017; 50(2): 64-8.
  21. Khazdair MR, Boskabady MH, Hosseini M, Rezaee R, Tsatsakis M. The effects of Crocus sativus (saffron) and its constituents on nervous system: A review. Avicenna J Phytomed 2015; 5(5): 376-91.
  22. Lopresti AL, Drummond PD. Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. J Affect Disord 2017; 207: 188-96.
  23. Ghajar A, Neishabouri SM, Velayati N, Jahangard L, Matinnia N, Haghighi M, et al. Crocus sativus L. versus citalopram in the treatment of major depressive disorder with anxious distress: A double-blind, controlled clinical trial. Pharmacopsychiatry 2017; 50(4): 152-60.
  24. Liu Z, Xu XH, Liu TY, Hong ZY, Urade Y, Huang ZL, et al. Safranal enhances non-rapid eye movement sleep in pentobarbital-treated mice. CNS Neurosci Ther 2012; 18(8): 623-30.
  25. Kuratsune H, Umigai N, Takeno R, Kajimoto Y, Nakano T. Effect of crocetin from Gardenia jasminoides Ellis on sleep: A pilot study. Phytomedicine 2010; 17(11): 840-3.
  26. Riazi A, Panahi Y, Alishiri AA, Hosseini MA, Karimi Zarchi AA, Sahebkar A. The impact of saffron (Crocus sativus) supplementation on visual function in patients with dry age-related macular degeneration. Italian Journal of Medicine 2017; 11(2): 196-201.
  27. Lashay A, Sadough G, Ashrafi E, Lashay M, Movassat M, Akhondzadeh S. Short-term outcomes of saffron supplementation in patients with age-related macular degeneration: A double-blind, placebo-controlled, randomized trial. Med Hypothesis Discov Innov Ophthalmol 2016; 5(1): 32-8.
  28. Jabbarpoor Bonyadi MH, Yazdani S, Saadat S. The ocular hypotensive effect of saffron extract in primary open angle glaucoma: a pilot study. BMC Complement Altern Med 2014; 14: 399.
  29. Marangoni D, Falsini B, Piccardi M, Ambrosio L, Minnella AM, Savastano MC, et al. Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: A preliminary report. J Transl Med 2013; 11: 228.
  30. Broadhead GK, Chang A, Grigg J, McCluskey P. Efficacy and safety of saffron supplementation: Current clinical findings. Crit Rev Food Sci Nutr 2016; 56(16): 2767-76.
  31. Agha-Hosseini M, Kashani L, Aleyaseen A, Ghoreishi A, Rahmanpour H, Zarrinara AR, et al. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: A double-blind, randomised and placebo-controlled trial. BJOG 2008; 115(4): 515-9.
  32. Modabbernia A, Sohrabi H, Nasehi AA, Raisi F, Saroukhani S, Jamshidi A, et al. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology (Berl) 2012; 223(4): 381-8.
  33. Kashani L, Raisi F, Saroukhani S, Sohrabi H, Modabbernia A, Nasehi AA, et al. Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study. Hum Psychopharmacol 2013; 28(1): 54-60.
  34. Shamsa A, Hosseinzadeh H, Molaei M, Shakeri MT, Rajabi O. Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. Phytomedicine 2009; 16(8): 690-3.
  35. Fukui H, Toyoshima K, Komaki R. Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus). Phytomedicine 2011; 18(8-9): 726-30.
  36. Khodakrami N, Moatar F, Ghahiri Aa. The effect of an iranian herbal drug on primary dysmenorrhoea - a clinical control trial. Ofogh-e-Danesh 2008; 14(1): 11-9. [In Persian].
  37. Mohammadzadeh-Moghadam H, Nazari SM, Shamsa A, Kamalinejad M, Esmaeeli H, Asadpour AA, et al. Effects of a topical saffron (Crocus sativus L) gel on erectile dysfunction in diabetics: A randomized, parallel-group, double-blind, placebo-controlled trial. J Evid Based Complementary Altern Med 2015; 20(4): 283-6.
  38. Razavi BM, Imenshahidi M, Abnous K, Hosseinzadeh H. Cardiovascular effects of saffron and its active constituents: A review article. Saffron agronomy and technology 2014; 1(2): 3-13.
  39. Safarinejad MR, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naive to treatment. Int J Impot Res 2010; 22(4): 240-50.
  40. Safarinejad MR, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia. Phytother Res 2011; 25(4): 508-16.
  41. Taavoni S, Ekbatani NN, Haghani H. Effect of Tribulus terrestris, ginger, saffron, and Cinnamomum on menopausal symptoms: A randomised, placebo-controlled clinical trial. Prz Menopauzalny 2017; 16(1): 19-22.
  42. Kamalipour M, Akhondzadeh S. Cardiovascular effects of saffron: an evidence-based review. J Tehran Heart Cent 2011; 6(2): 59-61.
  43. Verma SK, Bordia A. Antioxidant property of Saffron in man. Indian J Med Sci 1998; 52(5): 205-7.
  44. Azimi P, Ghiasvand R, Feizi A, Hariri M, Abbasi B. Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes patients. Rev Diabet Stud 2014; 11(3-4): 258-66.
  45. Milajerdi A, Jazayeri S, Bitarafan V, Hashemzadeh N, Shirzadi E, Derakhshan Z, et al. The effect of saffron (Crocus sativus L.) hydro-alcoholic extract on liver and renal functions in type 2 diabetic patients: A double-blinded randomized and placebo control trial. J Nutr Intermed Metab 2017; 9(Suppl C): 6-11.
  46. Hosseini A, Mousavi SH, Ghanbari A, Homaee SF, Raziee HR, Pezeshki RM, et al. Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial. Avicenna J Phytomed 2015; 5(5): 434-40.
  47. Mohamadpour AH, Ayati Z, Parizadeh MR, Rajbai O, Hosseinzadeh H. Safety evaluation of Crocin (a constituent of saffron) tablets in healthy volunteers. Iran J Basic Med Sci 2013; 16(1): 39-46.
  48. Modaghegh MH, Shahabian M, Esmaeili HA, Rajbai O, Hosseinzadeh H. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine 2008; 15(12): 1032-7.
  49. Ayatollahi H, Javan AO, Khajedaluee M, Shahroodian M, Hosseinzadeh H. Effect of Crocus sativus L. (saffron) on coagulation and anticoagulation systems in healthy volunteers. Phytother Res 2014; 28(4): 539-43.
  50. Mousavi B, Bathaie SZ, Fadai F, Ashtari Z, Ali BN, Farhang S, et al. Safety evaluation of saffron stigma (Crocus sativus L.) aqueous extract and crocin in patients with schizophrenia. Avicenna J Phytomed 2015; 5(5): 413-9.
  51. Fadai F, Mousavi B, Ashtari Z, Ali BN, Farhang S, Hashempour S, et al. Saffron aqueous extract prevents metabolic syndrome in patients with schizophrenia on olanzapine treatment: A randomized triple blind placebo controlled study. Pharmacopsychiatry 2014; 47(4-5): 156-61.
  52. Nikbakht-Jam I, Khademi M, Nosrati M, Eslami S, Foroutan-Tanha M, Sahebkar A, et al. Effect of crocin extracted from saffron on pro-oxidant-anti-oxidant balance in subjects with metabolic syndrome: A randomized, placebo-controlled clinical trial. Eur J Integr Med 2016; 8(3): 307-12.
  53. Kermani T, Mousavi SH, Shemshian M, Norouzy A, Mazidi M, Moezzi A, et al. Saffron supplements modulate serum pro-oxidant-antioxidant balance in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial. Avicenna J Phytomed 2015; 5(5): 427-33.
  54. Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, et al. Saffron in metabolic syndrome: Its effects on antibody titers to heat-shock proteins 27, 60, 65 and 70. J Complement Integr Med 2014; 11(1): 43-9.
  55. Nosrati M, Nikbakht-Jam I, Eslami S, Khademi M, Foroutan-Tanha M, Hadizadeh F, et al. Effect of crocin on antibody titers to heat-shock protein 27 in subjects with metabolic syndrome. Curr Clin Pharmacol 2017.
  56. Mizuma H, Tanaka M, Nozaki S, Mizuno K, Tahara T, Ataka S, et al. Daily oral administration of crocetin attenuates physical fatigue in human subjects. Nutr Res 2009; 29(3): 145-50.
  57. Varasteh A, Rahim ZM, Farid HR, Rouhani M. Determination of saffron (Crocus sativus) allergenicity. Iran J Basic Med Sci 2000; 3(1(6)):33-7.
  58. Gout B, Bourges C, Paineau-Dubreuil S. Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women. Nutr Res 2010; 30(5): 305-13.
مجله دانشکده پزشکی اصفهان
دوره 35، شماره 456 - شماره پیاپی 456
آذر و دی 1396
صفحه 1690-1699

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سابقه مقاله

  • تاریخ دریافت: 25 مرداد 1396
  • تاریخ بازنگری: 01 اردیبهشت 1403
  • تاریخ پذیرش: 17 فروردین 1401

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