تأثیر مکمل کیوتن در ناباروری مردان: یک مرور سیستماتیک بر روی مطالعات کارآزمایی بالینی

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه علوم بهداشتی در تغذیه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 گروه تغذیه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 دانشیار، گروه تغذیه‌ی جامعه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: ناباروری به عنوان عدم بارداری به دنبال داشتن رابطه‌ی جنسی در مدت حداقل یک سال در صورت عدم استفاده از هر گونه روش پیش‌گیری از بارداری تعریف می‌شود و ۱۵ درصد از افراد دنیا را درگیر کرده است که ۷۰-۲۰ درصد از موارد آن مربوط به مردان می‌باشد. مطالعات نشان می‌دهند که ناباروری با کاهش سطح کیوتن در سرم و مایع سمینال همراه است و دریافت مکمل آن، می‌تواند باعث کاهش علایم ناباروری و بهبود آن شود.روش‌ها: هدف از انجام مطالعه‌ی حاضر، مروری بر پژوهش‌های انجام گرفته برای بررسی رابطه‌ی کیوتن و ناباروری می‌باشد. مطالعات انجام شده‌ی مرتبط با اثر دریافت مکمل کیوتن بر ناباروری مردان از پایگاه‌های PubMed، Scopus، ISI و Google Scholar بین سال‌های 2017-2000 با کلید واژه‌های Coenzyme Q10، Ubiquinol-10، Infertility، Male Infertility، Male fertility problems، Semen parameters، Sexual dysfunction مورد بررسی قرار گرفتند.یافته‌ها: در بیشتر مطالعات کارآزمایی بالینی، مکمل کیوتن اثر مثبتی بر خصوصیات اسپرم از جمله غلظت، ریخت‌شناسی و حرکت داشت و همچنین، کاهش تخریب DNA را به همراه داشت. همچنین، سطح آنزیم‌های آنتی‌اکسیدانی کاتالاز و سوپراکسید دیسموتاز و همین‌طور، ظرفیت تام آنتی‌اکسیدانی نسبت به قبل از مداخله افزایش معنی‌داری داشت. با این وجود، برخی مطالعات اثر معنی‌داری از مکمل کیوتن بر خصوصیات اسپرم یافت نکردند.نتیجه‌گیری: در بیشتر مطالعات، تأثیر مثبت مکمل کیوتن بر روی پارامترهای اسپرمی، آسیب DNA، ظرفیت آنتی‌اکسیدانی و آنزیم‌‌های آنتی‌اکسیدانی اثبات شده است، اما به دلیل کم بودن مطالعات، انجام مطالعات کارآزمایی بیشتری در این زمینه لازم است.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Coenzyme Q10 Supplementation on Male Infertility: A Systematic Review on Randomized Clinical Trial Studies

نویسندگان [English]

  • Mehran Nouri 1
  • Keyhan Lotfi 2
  • Gholamreza Askari 3
1 MSc Student, Department of Health Sciences in Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
3 Associate Professor, Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Infertility is defined as failure in fertility after having sex for at least one year, if no contraceptive method is used, and 15% of the world's population is involved, of which 20-70 percent is related to men. Studies show that infertility is associated with a decrease in Q10 levels in the serum and seminal fluid, and its supplementation can reduce the symptoms of infertility, and improve it as well.Methods: The purpose of this study was to review the research done to investigate the relationship between Q10 and infertility. Clinical trial studies on the effect of supplementation of Q10 on male infertility from PubMed, Scopus, ISI, and Google Scholar databases between 2000 and 2017 were assessed using the keywords of coenzyme Q10, ubiquinol-10, infertility, male infertility, male fertility problems, semen parameters, sexual dysfunction.Findings: In most clinical trial studies, supplementation of Q10 had a positive effect on sperm parameters such as concentration, morphology, and movement. DNA fragmentation was also reduced; moreover, antioxidant enzymes of catalase and superoxide dismutase as well as total antioxidant capacity were significantly higher than before the intervention. However, some studies found no significant effect of Q10 on the sperm parameters.Conclusion: In most studies, the positive effects of Q10 supplement on sperm parameters, DNA damage, antioxidant capacity, and antioxidant enzymes have been proven, but due to the lack of studies, more clinical trial studies are needed in this area.

کلیدواژه‌ها [English]

  • Ceonzyme Q10
  • Ubiquinol-10
  • Fertility
  • Infertility
  • Male
  • Sperm
  • Sexual dysfunction
  • Physiological

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مجله دانشکده پزشکی اصفهان
دوره 36، شماره 504 - شماره پیاپی 504
آذر و دی 1397
صفحه 1401-1407

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سابقه مقاله

  • تاریخ دریافت: 24 تیر 1397
  • تاریخ بازنگری: 07 اردیبهشت 1403
  • تاریخ پذیرش: 17 فروردین 1401

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