Background: Patient safety is a fundamental challenge in healthcare systems, and nursing errors constitute a major threat to patient safety. Training nursing students in error management may be an effective strategy to reduce such errors. This study aimed to determine the effect of a blended error management training program in the emergency department.

Methods: This semi-experimental pretest–posttest study was conducted on 165 nursing students at Shahid Sadoughi University of Medical Sciences, Yazd, using a census sampling method. The training program was developed based on the ADDIE instructional design model, including analysis (qualitative study, learner analysis, and needs assessment), design (learning objectives and evaluation methods), development (content preparation, course design, and pilot implementation), implementation (blended course delivery), and evaluation (assessment of learning and reaction using the Kirkpatrick model). Data were collected using researcher-developed questionnaires and analyzed using descriptive statistics and paired t-tests.

Results: The mean learning score increased significantly from 6.78 ± 2.441 before the intervention to 12.36 ± 1.876 after the intervention (p < 0.001). Students’ satisfaction with the training program was at a desirable level. Reaction-level evaluation showed that all domains scored above the moderate level, with the highest scores related to course evaluation and instructional design and the lowest scores related to course content and technical aspects.

Conclusion: The blended error management training program demonstrated the potential to improve learning outcomes, reactions, and satisfaction among nursing students. However, due to the semi-experimental design, the findings should be interpreted with caution, and further controlled studies are recommended